Human immunodeficiency virus type 1 (HIV-1), the agent of AIDS, frequently infects the
central nervous system. We inoculated adult human brain cultures with chimeric viruses …

In the central nervous system of AIDS patients, human immunodeficiency virus (HIV) infects
primarily microglia, a cell type of bone marrow origin. Moreover, microglial cells isolated …

Human immunodeficiency virus type 1 (HIV-1) strains isolated from the central nervous
system (CNS) may represent a subgroup that displays a host cell tropism different from those …

Human immunodeficiency virus type 1 (HIV-1) infects and induces syncytium formation in
microglial cells from the central nervous system (CNS). A primary isolate (HIV-1BORI) was …

An accelerated, consistent macaque simian immunodeficiency virus (SIV) model in which
over 90% of pigtailed macaques (Macaca nemestrina) coinoculated with SIV/17E-Fr and …

To ascertain whether viruses present at the time of primary viremia can infect the central
nervous system and to determine if microglial tropism is distinct from tropism for monocyte …

HIV infects tissue macrophages and brain microglia, which express lower levels of CD4 and
CCR5 than CD4+ T cells in peripheral blood. Mechanisms that enhance HIV tropism for …

Background HIV-1 infects macrophages and microglia in the brain and can cause
neurological disorders in infected patients. We and others have shown that brain-derived …

HIV infects macrophages and microglia in the central nervous system (CNS), which express
lower levels of CD4 than CD4+ T cells in peripheral blood. To investigate mechanisms of …

Infection of the central nervous system by HIV-1, the agent of AIDS, is characterized by the
presence of infected and giant microglial cells as well as astrocytosis, demyelination, and …