It has been established in murine models that lymph nodes draining a progressively growing
tumor contain antigen-specific T cells capable of mediating protective immune responses …

Our laboratory has previously demonstrated that melanoma draining lymph node (MDLN)
samples from stage III patients contained both CD4+ and CD8+ T cells that can be readily …

BACKGROUND: Adoptive immunotherapy for patients with metastatic melanoma has
yielded encouraging results. However, methods of expanding melanoma-specific T cells …

Transformation of the pigment producing melanocytes into melanoma is a complex multi-
step process involving the enhanced expression of various antigens considered as …

Adoptive transfer of large numbers of tumor-reactive CD8+ cytotoxic T lymphocytes (CTLs)
expanded and differentiated in vitro has shown promising clinical activity against cancer …

MHC class I-restricted CTLs specific for antigens expressed by malignant cells are an
important component of immune responses against human cancer. Recently, in melanoma a …

Background. The purpose of this study was to determine the cellular effectors of both the
adoptively transferred cells and the tumor‐bearing host that participate in the antitumor …

In recent clinical trials in patients with metastatic melanoma, adoptive transfer of tumor-
reactive lymphocytes mediated the regression of metastatic tumor deposits. To better …

The adoptive transfer of immune T cells has been demonstrated to mediate regression of
established tumors in animals, with encouraging results in human clinical trials. In animal …

Five-year survival rates for patients diagnosed with metastatic melanoma are less than 5%.
Adoptive cell transfer (ACT) has achieved an objective response of 50% by Response …