Follicular helper T (Tfh) cells are necessary for germinal center (GC) formation and within
the GC, provide key signals to B cells for their differentiation into plasmablasts and plasma …

Follicular helper T (Tfh) cells provide crucial help to germinal center B (GCB) cells for proper
antibody production, and a specialized subset of regulatory T cells, follicular regulatory T …

The formation of high-affinity antibodies that protect against infection requires the formation
of germinal centres (GCs), where specialized T follicular helper cells (Tfh) provide help to B …

T follicular regulatory cells, or Tfr cells, are a discernable population of regulatory T (Treg)
cells that migrate to the B cell follicle and germinal center (GC) upon immune challenge …

High affinity antibodies result from interactions between B cells and T follicular helper (Tfh)
cells in germinal centers (GCs). Recent studies have identified an effector subset of T …

T follicular helper cells (Tfh cells) localize to follicles where they provide growth and
selection signals to mutated germinal center (GC) B cells, thus promoting their differentiation …

CD4+ follicular regulatory T (Tfr) cells suppress B cell responses through modulation of
follicular helper T (Tfh) cells and germinal center (GC) development. We found that Tfr cells …

Human and mouse studies performed over the last decade have established that follicular
helper T (Tfh) cells are a CD4+ helper subset specialized in the provision of help to B cells …

Germinal centers (GC) have been known as key anatomic structures in humoral immunity,
where isotype switching and affinity maturation occur. As a consequence, elucidation of GC …

Antibodies are powerful defense tools against pathogens but may cause autoimmune
diseases when erroneously directed toward self-antigens. Thus, antibody producing cells …