Folate plays a critical role in the prevention of uracil incorporation into DNA and
hypomethylation of DNA. This activity is compromised when vitamin B12 concentration is …

Folic acid plays a critical role in the prevention of chromosome breakage and
hypomethylation of DNA. This activity is compromised when Vitamin B12 (B12) …

Diet as a key factor in determining genomic stability is more important than previously
imagined because we now know it impacts on all relevant pathways, ie exposure to dietary …

Recommended dietary allowances (RDAs) of micronutrients have been traditionally derived
as those levels necessary to prevent symptoms of deficiency diseases. There is increasing …

Clinical vitamin B12 deficiency can result in megaloblastic anemia, which results from the
inhibition of DNA synthesis by trapping folate cofactors in the form of 5 …

A deficiency of any of the micronutrients: folic acid, Vitamin B12, Vitamin B6, niacin, Vitamin
C, Vitamin E, iron, or zinc, mimics radiation in damaging DNA by causing single-and double …

Despite unequivocal evidence that folate deficiency increases risk for human pathologies,
and that folic acid intake among women of childbearing age markedly decreases risk for …

Folic acid deficiency in humans has been linked with megaloblastic anaemia, neural tube
defects in the neonate, and heart disease. Folate has also been implicated in the …

Folate deficiency causes massive incorporation of uracil into human DNA (4 million per cell)
and chromosome breaks. The likely mechanism is the deficient methylation of dUMP to …

We performed a cross-sectional study (n= 49 males, 57 females) and a randomized double-
blind placebo-controlled dietary intervention study (n= 31/32 per group) to determine the …