Apoptosis resistance is to a large extent a major obstacle leading to chemotherapy failure
during cancer treatment. Bypassing the apoptotic pathway to induce cancer cell death is …

Necroptosis, an important form of programmed cell death (PCD), is a highly regulated
caspase-independent type of cell death that plays a critical role in the pathophysiology of …

Necrosis is often viewed as an accidental and unregulated cellular event. However,
accumulating evidence suggests that necrosis, like apoptosis, can be executed by regulated …

Necroptosis, a distinctive type of programmed cell death different from apoptosis or necrosis,
triggered by a series of death receptors such as tumor necrosis factor receptor 1 (TNFR1) …

Necroptosis was initially identified as a backup cell death program when apoptosis is
blocked. However, it is now recognized as a cellular defense mechanism against infections …

Necroptosis and pyroptosis are inflammatory forms of regulated necrotic cell death as
opposed to apoptosis that is generally considered immunologically silent. Recent studies …

Necroptosis is a lytic, proinflammatory cell death pathway, which has been implicated in host
defense and, when dysregulated, the pathology of many human diseases. The central …

One of the hallmarks of cancer is resistance to programmed cell death, which maintains the
survival of cells en route to oncogenic transformation and underlies therapeutic resistance …

Necroptosis is a programmed lytic cell death pathway, deregulation of which is linked to
various inflammatory disorders. Escape from programmed cell death and inflammation play …

As an important type of programmed cell death in addition to apoptosis, necroptosis occurs
in a variety of pathophysiological processes, including infections, liver diseases, kidney …