Programmed cell death (PCD) has been a major area of constantly growing interest over the
last three decades. Originally, apoptosis was considered the only mechanistic pathway for …

Cell death is an essential process in all living organisms and occurs through different
mechanisms. The three main types of programmed cell death are apoptosis, pyroptosis, and …

Cell proliferation and cell death are integral elements in maintaining homeostatic balance in
metazoans. Disease pathologies ensue when these processes are disturbed. A plethora of …

Microbial infection and tissue injury are well established as the two major drivers of
inflammation. However, although it is widely accepted that necrotic cell death can trigger or …

While the mechanisms underlying apoptosis and autophagy have been well characterized
over recent decades, another regulated cell death event, necroptosis, remains poorly …

A process of regulated necrosis, termed necroptosis, has been recognized as a major
contributor to cell death and inflammation occurring under a wide range of pathologic …

Apoptosis is a programmed form of cell death with well-defined morphological traits that are
often associated with activation of caspases. More recently evidence has become available …

The necroptosis cell death pathway has been implicated in host defense and in the
pathology of inflammatory diseases. While phosphorylation of the necroptotic effector …

Necroptosis (programmed necrosis) occurs in response to TNF, Fas, or TRAIL, as well as
certain TLR ligands, when caspase activity required for apoptosis is blocked. Necroptosis is …

Cell death is a fundamental physiological process in all living organisms. Its roles extend
from embryonic development, organ maintenance, and aging to the coordination of immune …