Stimulation of death receptors by agonists such as FasL and TNFα activates apoptotic cell
death in apoptotic-competent conditions or a type of necrotic cell death dependent on RIP1 …

Contrary to the apoptosis-necrosis binary view of cell death, recent experimental evidence
demonstrates that several forms of necrosis, represented by necroptosis, are regulated or …

Immune-checkpoint blockers (ICBs) have revolutionized oncology and firmly established the
subfield of immuno-oncology. Despite this renaissance, a subset of cancer patients remain …

Necroptosis is a form of regulated cell death that has been implicated in multiple diseases.
TNF-induced necroptosis is regulated by necrosomes, complexes consisting of RIPK1 …

Necrosis of a cell is defined by the loss of its plasma membrane integrity. Morphologically,
necrosis occurs in several forms such as coagulative necrosis, colliquative necrosis …

While apoptosis has been considered to be identical to programmed cell death, necroptosis,
which is morphologically related to necrosis, has emerged as a novel type of programmed …

Necroptosis is a noncaspase-dependent and precisely regulated mechanism of cell death.
Necroptosis is mainly initiated by members of the tumor necrosis factor receptor (TNFR) and …

Over last decades, most antitumor therapeutic strategies have focused on apoptosis,
however, apoptosis resistance and immunological silence usually led to treatment failure. In …

Pyroptosis and necroptosis represent two pathways of genetically encoded necrotic cell
death. Although these cell death programmes can protect the host against microbial …

Neuroinflammation is a complex inflammatory process in the nervous system that is
expected to play a significant role in neurological diseases. Necroptosis is a kind of necrosis …