Background Although the relationship of elevated serum uric acid levels and cardiovascular
disease has been established in a great number of studies, the causal relevance of this …

Background Mendelian Randomization (MR) studies show conflicting causal associations of
genetically predicted serum urate with cardiovascular risk factors (ie, hypertension, diabetes …

Objectives To assess the associations between both uric acid levels and hyperuricaemia,
with ischaemic heart disease and blood pressure, and to explore the potentially confounding …

Obesity and diets rich in uric acid–raising components appear to account for the increased
prevalence of hyperuricemia in Westernized populations. Prevalence rates of hypertension …

Background Higher serum uric acid levels are associated with cardiovascular and
neurovascular disease, but whether these relationships are causal is not known. We applied …

High levels of serum uric acid are associated with hypertension in observational studies.
The aim of this study was to investigate the association of uric acid gene variants with blood …

Background Increased circulating plasma urate concentration is associated with an
increased risk of coronary heart disease, but the extent of any causative effect of urate on …

Background The role of urate in cardiovascular diseases (CVDs) has been extensively
investigated in observational studies; however, the extent of any causal effect remains …

Serum urate has been implicated in hypertension and cardiovascular disease, but it is not
known whether it is exerting a causal effect. To investigate this, we performed Mendelian …

Background: Although epidemiological studies have reported positive associations between
circulating urate levels and cardiometabolic diseases, causality remains uncertain …