Effect of tocilizumab on clinical outcomes at 15 days in patients with severe or critical coronavirus disease 2019: randomised controlled trial

VC Veiga, JAGG Prats, DLC Farias, RG Rosa… - bmj, 2021 - bmj.com
Objective To determine whether tocilizumab improves clinical outcomes for patients with
severe or critical coronavirus disease 2019 (covid-19). Design Randomised, open label trial …

[HTML][HTML] The effect of tocilizumab on mortality in hospitalized patients with COVID-19: a meta-analysis of randomized controlled trials

CS Kow, SS Hasan - European journal of clinical pharmacology, 2021 - Springer
Objective We aimed to perform a meta-analysis of randomized controlled trials (RCTs) to
summarize the overall effect of tocilizumab on the risk of mortality among patients with …

[HTML][HTML] Use of tocilizumab in COVID-19: a systematic review and meta-analysis of current evidence

S Kotak, M Khatri, M Malik, M Malik, W Hassan… - Cureus, 2020 - ncbi.nlm.nih.gov
Materials and methods Online databases (PubMed and Cochrane) were searched until
June 29, 2020, for original articles investigating the immunological response in COVID-19 …

[HTML][HTML] Effect of tocilizumab in hospitalized patients with severe COVID-19 pneumonia: a case-control cohort study

B Rossi, LS Nguyen, P Zimmermann, F Boucenna… - Pharmaceuticals, 2020 - mdpi.com
Tocilizumab, an anti-interleukin-6 receptor, administrated during the right timeframe may be
beneficial against coronavirus-disease-2019 (COVID-19) pneumonia. All patients admitted …

Tocilizumab in patients hospitalized with COVID-19 pneumonia: systematic review and meta-analysis of randomized controlled trials

S Gupta, RP Padappayil, A Bansal… - Journal of …, 2022 - journals.sagepub.com
Tocilizumab is an interleukin receptor inhibitor that has been used in patients with COVID-19
pneumonia. There are recent randomized controlled trials (RCTs) that evaluated the efficacy …

[HTML][HTML] Efficacy and safety of tocilizumab in COVID-19 patients: a living systematic review and meta-analysis, first update

IM Tleyjeh, Z Kashour, M Riaz, L Hassett… - Clinical Microbiology …, 2021 - Elsevier
Objectives Cytokine release syndrome with elevated interleukin-6 (IL-6) levels is associated
with multiorgan damage and death in severe coronavirus disease 2019 (COVID-19). Our …

[HTML][HTML] Efficacy and safety of tocilizumab in COVID-19 patients: a living systematic review and meta-analysis

IM Tleyjeh, Z Kashour, M Damlaj, M Riaz… - Clinical Microbiology …, 2021 - Elsevier
Objectives Cytokine release syndrome with elevated interleukin-6 (IL-6) levels is associated
with multiorgan damage and death in severe coronavirus disease 2019 (COVID-19). Our …

[HTML][HTML] Tocilizumab in the treatment of critical COVID-19 pneumonia: A retrospective cohort study of mechanically ventilated patients

MJ Fisher, LAM Raymundo, M Monteforte… - International Journal of …, 2021 - Elsevier
Objectives The purpose of this study is to evaluate clinical outcomes in patients with critical
COVID-19 pneumonia requiring invasive mechanical ventilation who were treated with …

Efficacy and safety of tocilizumab versus standard care/placebo in patients with COVID‐19; a systematic review and meta‐analysis of randomized clinical trials

D Vela, Z Vela‐Gaxha, M Rexhepi… - British Journal of …, 2022 - Wiley Online Library
Aims Tocilizumab has emerged as an important therapy in treating patients with coronavirus
disease (COVID‐19). Our purpose was to evaluate the efficacy and safety of tocilizumab …

[HTML][HTML] Tocilizumab in patients with severe COVID-19: a retrospective cohort study

G Guaraldi, M Meschiari, A Cozzi-Lepri… - The Lancet …, 2020 - thelancet.com
Background No therapy is approved for COVID-19 pneumonia. The aim of this study was to
assess the role of tocilizumab in reducing the risk of invasive mechanical ventilation and …