The carbon monoxide‐releasing molecule, corm‐3 (ru(co)3cl(glycinate)), targets respiration and oxidases in campylobacter jejuni, generating hydrogen peroxide
H Smith, BE Mann, R Motterlini, RK Poole - IUBMB life, 2011 - Wiley Online Library
Carbon monoxide (CO) is a classical respiratory inhibitor, but CO‐releasing molecules (CO‐
RMs) have therapeutic value, increasing phagocytosis, and reducing sepsis‐induced …
RMs) have therapeutic value, increasing phagocytosis, and reducing sepsis‐induced …
Carbon monoxide-releasing antibacterial molecules target respiration and global transcriptional regulators
KS Davidge, G Sanguinetti, CH Yee, AG Cox… - Journal of Biological …, 2009 - ASBMB
Carbon monoxide, a classical respiratory inhibitor, also exerts vasodilatory, anti-
inflammatory, and antiapoptotic effects. CO-releasing molecules have therapeutic value …
inflammatory, and antiapoptotic effects. CO-releasing molecules have therapeutic value …
Ru(CO)3Cl(Glycinate) (CORM-3): A Carbon Monoxide–Releasing Molecule with Broad-Spectrum Antimicrobial and Photosensitive Activities Against Respiration and Cation …
JL Wilson, HE Jesse, B Hughes, V Lund… - Antioxidants & redox …, 2013 - liebertpub.com
Aims: Carbon monoxide (CO) delivered to cells and tissues by CO-releasing molecules (CO-
RMs) has beneficial and toxic effects not mimicked by CO gas. The metal carbonyl Ru (CO) …
RMs) has beneficial and toxic effects not mimicked by CO gas. The metal carbonyl Ru (CO) …
Analysis of the Bacterial Response to Ru(CO)3Cl(Glycinate) (CORM-3) and the Inactivated Compound Identifies the Role Played by the Ruthenium Compound and …
S McLean, R Begg, HE Jesse, BE Mann… - Antioxidants & redox …, 2013 - liebertpub.com
Abstract Aims: Carbon monoxide (CO)-releasing molecules (CO-RMs) are being developed
with the ultimate goal of safely utilizing the therapeutic potential of CO clinically. One such …
with the ultimate goal of safely utilizing the therapeutic potential of CO clinically. One such …
'Carbon-monoxide-releasing molecule-2 (CORM-2)'is a misnomer: ruthenium toxicity, not CO release, accounts for its antimicrobial effects
HM Southam, MP Williamson, JA Chapman, RL Lyon… - Antioxidants, 2021 - mdpi.com
Carbon monoxide (CO)-releasing molecules (CORMs) are used to deliver CO, a biological
'gasotransmitter', in biological chemistry and biomedicine. CORMs kill bacteria in culture and …
'gasotransmitter', in biological chemistry and biomedicine. CORMs kill bacteria in culture and …
Metabolomics of Escherichia coli Treated with the Antimicrobial Carbon Monoxide-Releasing Molecule CORM-3 Reveals Tricarboxylic Acid Cycle as Major Target
In the last decade, carbon monoxide-releasing molecules (CORMs) have been shown to act
against several pathogens and to be promising antimicrobials. However, the understanding …
against several pathogens and to be promising antimicrobials. However, the understanding …
[HTML][HTML] A thiol-reactive Ru (II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3
HM Southam, TW Smith, RL Lyon, C Liao, CR Trevitt… - Redox biology, 2018 - Elsevier
Carbon monoxide (CO)-releasing molecules (CORMs), mostly metal carbonyl compounds,
are extensively used as experimental tools to deliver CO, a biological 'gasotransmitter', in …
are extensively used as experimental tools to deliver CO, a biological 'gasotransmitter', in …
CO-Releasing Molecules Have Nonheme Targets in Bacteria: Transcriptomic, Mathematical Modeling and Biochemical Analyses of CORM-3 [Ru(CO)3Cl(glycinate)] Actions on …
JL Wilson, LK Wareham, S McLean, R Begg… - Antioxidants & redox …, 2015 - liebertpub.com
Aims: Carbon monoxide-releasing molecules (CORMs) are being developed with the
ultimate goal of safely utilizing the therapeutic potential of CO clinically, including …
ultimate goal of safely utilizing the therapeutic potential of CO clinically, including …
Interaction of the carbon monoxide-releasing molecule Ru(CO)3Cl(glycinate) (CORM-3) with Salmonella enterica serovar Typhimurium: in situ measurements of …
N Rana, S McLean, BE Mann, RK Poole - Microbiology, 2014 - microbiologyresearch.org
Carbon monoxide (CO) is a toxic gas that binds to haems, but also plays critical signalling
and cytoprotective roles in mammalian systems; despite problems associated with systemic …
and cytoprotective roles in mammalian systems; despite problems associated with systemic …
[HTML][HTML] Cytochrome bd-I in Escherichia coli is less sensitive than cytochromes bd-II or bo′'to inhibition by the carbon monoxide-releasing molecule, CORM-3: N …
HE Jesse, TL Nye, S McLean, J Green, BE Mann… - … et Biophysica Acta (BBA …, 2013 - Elsevier
Background: CO-releasing molecules (CO-RMs) are potential therapeutic agents, able to
deliver CO–a critical gasotransmitter–in biological environments. CO-RMs are also effective …
deliver CO–a critical gasotransmitter–in biological environments. CO-RMs are also effective …
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