[HTML][HTML] Nuclear export of NF90 is required for interleukin-2 mRNA stabilization
In response to T cell activation signals, the half-life of interleukin-2 (IL-2) mRNA is greatly
extended. The cis elements mediating IL-2 mRNA stabilization are located in its 5′ and 3 …
extended. The cis elements mediating IL-2 mRNA stabilization are located in its 5′ and 3 …
IL-2 mRNA stabilization upon PMA stimulation is dependent on NF90-Ser647 phosphorylation by protein kinase CβI
IL-2 is an important cytokine produced in T cells in response to Ag or mitogen stimulation. It
is regulated at both transcriptional and posttranscriptional levels. One of the key regulators …
is regulated at both transcriptional and posttranscriptional levels. One of the key regulators …
Nuclear export of NF90 to stabilize IL-2 mRNA is mediated by AKT-dependent phosphorylation at Ser647 in response to CD28 costimulation
IL-2 is one of the most important cytokines required for T cell-mediated immune responses.
Costimulation of CD28 in T cells up-regulates IL-2 mRNA levels via transcription activation …
Costimulation of CD28 in T cells up-regulates IL-2 mRNA levels via transcription activation …
Destabilization of interleukin-6 mRNA requires a putative RNA stem-loop structure, an AU-rich element, and the RNA-binding protein AUF1
S Paschoud, AM Dogar, C Kuntz… - … and cellular biology, 2006 - Am Soc Microbiol
Interleukin-6 mRNA is unstable and degraded with a half-life of 30 min. Instability
determinants can entirely be attributed to the 3′ untranslated region. By grafting segments …
determinants can entirely be attributed to the 3′ untranslated region. By grafting segments …
Regulation of nuclear gamma interferon gene expression by interleukin 12 (IL-12) and IL-2 represents a novel form of posttranscriptional control
DL Hodge, A Martinez, JG Julias… - … and cellular biology, 2002 - Taylor & Francis
Posttranscriptional control of gamma interferon (IFN-γ) gene expression has not been
extensively studied and is poorly understood. Our work describes a posttranscriptional …
extensively studied and is poorly understood. Our work describes a posttranscriptional …
NF90 selectively represses the translation of target mRNAs bearing an AU-rich signature motif
Y Kuwano, R Pullmann Jr, BS Marasa… - Nucleic acids …, 2010 - academic.oup.com
The RNA-binding protein nuclear factor 90 (NF90) has been implicated in the stabilization,
transport and translational control of several target mRNAs. However, a systematic analysis …
transport and translational control of several target mRNAs. However, a systematic analysis …
Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation
CY Chen, R Gherzi, JS Andersen… - Genes & …, 2000 - genesdev.cshlp.org
Regulated mRNA turnover is a highly important process, but its mechanism is poorly
understood. Using interleukin-2 (IL-2) mRNA as a model, we described a role for the JNK …
understood. Using interleukin-2 (IL-2) mRNA as a model, we described a role for the JNK …
[HTML][HTML] The carboxyl terminus of interferon-γ contains a functional polybasic nuclear localization sequence
PS Subramaniam, MG Mujtaba, MR Paddy… - Journal of Biological …, 1999 - ASBMB
Cytokines such as interferon-gamma (IFN-γ), which utilize the well studied JAK/STAT
pathway for nuclear signal transduction, are themselves translocated to the nucleus. The …
pathway for nuclear signal transduction, are themselves translocated to the nucleus. The …
The NF45/NF90 heterodimer contributes to the biogenesis of 60S ribosomal subunits and influences nucleolar morphology
F Wandrey, C Montellese, K Koos… - … and cellular biology, 2015 - Am Soc Microbiol
The interleukin enhancer binding factors ILF2 (NF45) and ILF3 (NF90/NF110) have been
implicated in various cellular pathways, such as transcription, microRNA (miRNA) …
implicated in various cellular pathways, such as transcription, microRNA (miRNA) …
Enhanced stability of interleukin-2 mRNA in MLA 144 cells. Possible role of cytoplasmic AU-rich sequence-binding proteins.
T Henics, A Sanfridson, BJ Hamilton, E Nagy… - Journal of Biological …, 1994 - ASBMB
The MLA 144 gibbon T cell line is infected with a type C retrovirus and constitutively
expresses interleukin-2 (IL-2) and granulocyte macrophage colony-stimulating factor (GM …
expresses interleukin-2 (IL-2) and granulocyte macrophage colony-stimulating factor (GM …