Background Although increasing evidence has indicated that brain insulin dysfunction is a
risk factor for Alzheimer disease (AD), the underlying mechanisms by which insulin …

Although evidence is accumulating that diabetes mellitus is an important risk factor for
sporadic Alzheimer's disease (AD), the mechanisms by which defects in insulin signaling …

Background Based on epidemiological and experimental studies, type 2 diabetes mellitus
(T2DM), especially insulin resistance that comprises the core mechanism of T2DM, has …

Alzheimer's disease (AD) has characteristic neuropathological abnormalities including
regionalized neurodegeneration, neurofibrillary tangles, amyloid beta (Aβ) deposition …

A number of studies suggest an association between Alzheimer's disease (AD) and
diabetes: AD patients show impaired insulin function, whereas cognitive deficits and …

Reduced glucose utilization is likely to precede the onset of cognitive deficits in Alzheimer's
disease (AD). Similar aberrant glucose metabolism can also be detected in the brain of …

Defects in insulin production and signaling are suspected to share a key role in diabetes
and Alzheimer disease (AD), two age-related pathologies. In this study, we investigated the …

Recent epidemiological evidence indicates that insulin resistance, a proximal cause of Type
II diabetes [a non‐insulin dependent form of diabetes mellitus (NIDDM)], is associated with …

Individuals with type 2 diabetes have an increased risk for developing Alzheimer's disease
(AD), although the causal relationship remains poorly understood. Alterations in insulin …

Hyperinsulinemia is a risk factor for late-onset Alzheimer's disease (AD). In vitro experiments
describe potential connections between insulin, insulin signaling, and amyloid-β (Aβ), but in …