Antidepressants exhibit a number of pharmacological mechanisms, including
norepinephrine and serotonin modulation, direct and indirect effects on opioid receptors …

This structured review addresses the issue of whether antidepressants have an
antinociceptive (analgesic) effect for chronic pain independent of their antidepressant effect …

Depression and painful somatic symptoms commonly occur together. Depression and
chronic pain can have devastating effects on a patient's health, productivity, and overall …

There is a high prevalence of chronic pain disorders in the population and the individual and
societal costs are large. Antidepressants have been used in the treatment of chronic pain …

Background Studies suggest that poor physical health might be associated with increased
depression and anxiety recurrence. The objectives of this study were to determine whether …

Background Pain is a common symptom in patients with depressive disorders, which, if
present, worsens the prognosis. However, there is little empirical knowledge of the …

Depressive disorders are chronic conditions that produce both emotional and physical
symptoms. Increasing evidence suggests that in some patients with depressive disorders a …

Persistent pain disorders are usually not adequately alleviated by nonsteroidal anti‐
inflammatory drugs or other simple analgesics. Use of antidepressants as adjuvant therapy …

Neither pain, nor depression exist as independent phenomena per se, they are highly
subjective inner states, formed by our brain and built on the bases of our experiences …

Abstract Purpose of Review While clinicians have been using antidepressants for off-label
indications in the treatment of chronic pain in recent years, newer studies have proven …