Neuropathic pain can be caused by multiple factors, and its prevalence can reach 10% of
the global population. It is becoming increasingly evident that limited or short-lasting …

Recent research advances indicate that specialized neural pathways are involved in the
encoding of pain sensations and that these pathways are sensitive to changes in stimulus …

The current knowledge of the pharmacological actions of the tricyclic antidepressants
(TCAs) has slowly evolved through their over 40-year history. Chronic pain represents one …

Although clinical studies suggest depressed patients may be more vulnerable to pain,
experimental research is equivocal. This meta-analysis aimed to clarify whether depression …

Pain is a subjective experience that is influenced by genetics, gender, social, cultural and
personal parameters. Opposed to chronic pain, which by definition has to last for at least 3 …

Background Approximately two-thirds of patients with depression experience physical pain
symptoms. Coexisting pain complicates the treatment of depression and is associated with …

This article presents the findings of a focused literature review and consensus meetings on
the definition and clinical significance of painful symptoms in patients with depression. About …

Chronic primary pain (CPP) is a group of diseases with long‐term pain and functional
disorders but without structural or specific tissue pathologies. CPP is becoming a serious …

Antidepressant drugs have been widely used for many years to treat neuropathic pain,
despite the rationale for their use was still unclear. We review recent insights into their …

Objective Pain commonly coexists with depression, but its impact on treatment outcomes
has not been well studied. Therefore, we prospectively evaluated the impact of comorbid …