BACKGROUND & AIMS:: Colorectal cancer is one of the leading causes of cancer death.
Most colorectal cancers are believed to develop from colorectal adenomas. We examined …

Background & Aims: In human and animal studies, nonsteroidal anti-inflammatory drugs
have been associated with a reduced risk of colorectal neoplasia. Although the underlying …

Background & Aims: Our aim was to establish the incidence of symptomatic upper
gastrointestinal ulcers, ulcer perforation, ulcer obstruction, or bleeding episodes (PUBs) …

Introduction Nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to have a
property to inhibit tumor development in some cancers while it shows various side effects …

Background Selective inhibition of cyclooxygenase-2 (COX-2) may be associated with an
increased risk of thrombotic events, but only limited long-term data have been available for …

Background Studies showing that drugs that inhibit cyclooxygenase-2 (COX-2) reduce the
number of colorectal adenomas in animals and patients with familial adenomatous …

Chemopreventive strategies for colorectal cancer (CRC) have been extensively studied to
prevent the recurrence of adenomas and/or delay their development in the gastrointestinal …

Background Overexpression of cyclooxygenase 2 (COX-2) has been associated with
colorectal adenomatous polyps and cancer, prompting researchers to propose its inhibition …

This article discusses the merits and limits of nonsteroidal antiinflammatory drugs (NSAIDs),
including cyclooxygenase (COX)-2 inhibitors, for colorectal cancer prevention. The …

Abstract Selective cyclooxygenase (COX)-2 inhibitors (coxibs) were developed as one of the
anti-inflammatory drugs to avoid the various side effects of non-steroidal anti-inflammatory …