The seminal epidemiological observation that nonsteroidal anti-inflammatory drugs
(NSAIDs) prevent colon and possibly other cancers has spurred novel approaches to cancer …

The cyclooxygenase (COX) enzymes (COX-1 and COX-2) are key enzymes of prostaglandin
(PG) biosynthesis. Nonselective non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the …

CRC development is a multi-step process that spans 10 to 15 years, thereby providing an
opportunity for early detection and even prevention. The poor survival rate of advanced CRC …

The cyclooxygenase (COX) pathway is important in colorectal carcinogenesis with the
majority of cancers overexpressing COX-2; however, the role of COX-2 in the development …

Cyclooxygenase (COX), a key enzyme in the prostanoid biosynthetic pathway, has received
considerable attention due to its role in human cancers. Observational and randomized …

Epidemiologic studies have documented a 40–50% reduction in incidence of colorectal
cancer in individuals taking nonsteroidal antiinflammatory drugs (NSAIDs). Since NSAIDs …

There is considerable interest in the involvement of cyclooxygenase-2 (COX-2) in colon
carcinogenesis and its progression, because nonsteroidal anti-inflammatory drugs (NSAIDs) …

Since colorectal cancer is one of the world's most common cancers, studies on its prevention
and early diagnosis are an emerging area of clinical oncology these days. For this study, a …

There is a wealth of evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) can
prevent colorectal cancer. In this article the role of cyclooxygenase 1 and 2, the principle …

Epidemiological and laboratory studies indicate an inverse relationship between the risk of
colon cancer development and intake of nonsteroidal antiinflammatory agents, including …