Chronic heart failure is debilitating, often fatal, expensive to treat and common. In most
patients it is a late consequence of myocardial infarction (MI). The intracellular signals …

The p38 mitogen-activated protein kinases (p38s) are Ser/Thr kinases that are activated as a
result of cellular stresses and various pathological conditions, including myocardial …

This minireview discusses the evidence that the inhibition of p38 mitogen-activated protein
kinases (p38 MAPKs) maybe of therapeutic value in heart failure. Most previous …

Phosphorylation is the process through which extracellular signals are communicated to the
interior of the cell and it is catalyzed by kinases. The protein kinases transfer the terminal …

p38 Mitogen-activated protein kinase (MAPK) has been implicated in cardiovascular
disease and is activated by various factors, including neurohormones (eg, catecholamines …

Abstract p38 mitogen-activated protein kinases (p38 MAPKs) are key signalling molecules
that regulate cellular behavior in response to environmental stresses. They regulate pro …

The p38 mitogen-activated kinase (MAPK) family controls cell adaptation to stress stimuli.
p38 function has been studied in depth in relation to cardiac development and function. The …

The p38 mitogen-activated protein kinases (p38s) are stress-activated Ser/Thr kinases. Their
activation has been associated with various pathological stressors in the heart. Activated …

The p38-MAPK pathway plays an important role in myocardial ischaemia/reperfusion injury
and has been implicated in the regulation of cardiac gene expression, myocyte hypertrophy …

Abstract p38 kinases are members of the mitogen-activated protein kinases (MAPK) with
established contribution to a wide range of signaling pathways and different biological …