Correlation of EGFR Mutation Status With Predominant Histologic Subtype of Adenocarcinoma According to the New Lung Adenocarcinoma Classification of the …

C Villa, PT Cagle, M Johnson… - … of Pathology and …, 2014 - meridian.allenpress.com
Context.—Epidermal growth factor receptor (EGFR) mutations have been identified as
predictors of response to EGFR tyrosine kinase inhibitors in non–small cell lung cancer …

KRAS Mutation Is an Important Predictor of Resistance to Therapy with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non–Small-Cell Lung Cancer

E Massarelli, M Varella-Garcia, X Tang, AC Xavier… - Clinical cancer …, 2007 - AACR
Purpose: EGFR gene mutations and increased EGFR copy number have been associated
with favorable response to epidermal growth factor receptor (EGFR) tyrosine kinase …

Identification of EGFR kinase domain mutations among lung cancer patients in China: implication for targeted cancer therapy

BM Qin, X Chen, JD ZHU, DQ Pei - Cell Research, 2005 - nature.com
Lung cancer is one of the leading causes of death with one of the lowest survival rates.
However, a subset of lung cancer patients who are of Asian origin and carry somatic …

Heterogeneous Distribution of EGFR Mutations Is Extremely Rare in Lung Adenocarcinoma

Y Yatabe, K Matsuo, T Mitsudomi - Journal of Clinical Oncology, 2011 - ascopubs.org
Purpose Some studies have shown that epidermal growth factor receptor (EGFR) mutations
can be heterogeneously distributed in individual tumors. In this study, we re-evaluated the …

Incidence of EGFR Exon 19 Deletions and L858R in Tumor Specimens From Men and Cigarette Smokers With Lung Adenocarcinomas

SP D'Angelo, MC Pietanza, ML Johnson… - Journal of clinical …, 2011 - ascopubs.org
Purpose EGFR mutations underlie the sensitivity of lung cancers to erlotinib and gefitinib
and can occur in any patient with this illness. Here we examine the frequency of EGFR …

Frequency of and variables associated with the EGFR mutation and its subtypes

T Tanaka, M Matsuoka, A Sutani… - … journal of cancer, 2010 - Wiley Online Library
Mutation in the epidermal growth factor receptor (EGFR) is frequently seen in non‐small cell
lung cancers (NSCLCs), especially in Asian females with adenocarcinoma. The frequency of …

[HTML][HTML] An alternative method for screening EGFR mutation using RFLP in non-small cell lung cancer patients

I Kawada, K Soejima, H Watanabe, I Nakachi… - Journal of Thoracic …, 2008 - Elsevier
Introduction Epidermal growth factor receptor (EGFR) mutations are strong determinants of
tumor response to EGFR tyrosine kinase inhibitors in non-small cell lung cancers (NSCLCs) …

Role of EGFR mutations in lung cancers: prognosis and tumor chemosensitivity

K Suda, T Mitsudomi - Archives of toxicology, 2015 - Springer
Lung cancers with an epidermal growth factor receptor (EGFR) gene mutation account for~
40% of adenocarcinomas in East Asians and~ 15% of those in Caucasians and African …

Epidermal growth factor receptor mutations in non–small-cell lung cancer: Implications for treatment and tumor biology

PA Jänne, JA Engelman, BE Johnson - Journal of clinical oncology, 2005 - ascopubs.org
The epidermal growth factor receptor (EGFR) has emerged as an attractive therapeutic
target for patients with non–small-cell lung cancer (NSCLC). However, despite its almost …

Epidermal growth factor receptor and KRAS mutations in Brazilian lung cancer patients

CE Bacchi, H Ciol, EM Queiroga, LC Benine, LH Silva… - Clinics, 2012 - SciELO Brasil
OBJECTIVE: Epidermal growth factor receptor is involved in the pathogenesis of non-small
cell lung cancer and has recently emerged as an important target for molecular therapeutics …