There is increasing evidence of a causal relationship between sleep-disordered breathing
and metabolic dysfunction. Metabolic syndrome (MetS), a cluster of risk factors that promote …

Obstructive sleep apnea (OSA) is a very prevalent breathing disorder (Peppard et al., 2013;
Heinzer et al., 2015) characterized by recurrent obstructions of the upper airway during …

We aimed to identify novel molecular associations between chronic intermittent hypoxia with
re-oxygenation and adverse consequences in obstructive sleep apnea (OSA). We analyzed …

Abstract Study Objectives Chronic intermittent hypoxia (CIH) is a major determinant in
obstructive sleep apnea cardiovascular morbidity and this effect is influenced by age. The …

Background Many have assumed that the primary function of sleep is for the brain. We
evaluated the molecular consequences of sleep and sleep deprivation outside the brain, in …

Obstructive sleep apnea (OSA) is common and linked to a variety of poor health outcomes. A
key modulator of this disease is nocturnal intermittent hypoxia. There is striking …

Obstructive sleep apnoea syndrome is a growing health concern, affecting nearly one billion
people worldwide; it is an independent cardiovascular risk factor, associated with incident …

The function of the circadian cycle is to determine the natural 24 h biological rhythm, which
includes physiological, metabolic, and hormonal changes that occur daily in the body. This …

Obstructive sleep apnea (OSA) is a chronic disorder characterized by recurrent episodes of
apnea and hypopnea during sleep. It is associated with various cardiovascular and …

There is increasing evidence that intermittent hypoxia plays a role in the development of
cardiovascular risk in obstructive sleep apnoea syndrome (OSAS) through the activation of …