[HTML][HTML] Intermittent hypoxia causes histological kidney damage and increases growth factor expression in a mouse model of obstructive sleep apnea

B Abuyassin, M Badran, NT Ayas, I Laher - PLoS One, 2018 - journals.plos.org
Epidemiological studies demonstrate an association between obstructive sleep apnea
(OSA) and accelerated loss of kidney function. It is unclear whether the decline in function is …

Intermittent hypoxia, respiratory plasticity and sleep apnea in humans: present knowledge and future investigations

JH Mateika, Z Syed - Respiratory physiology & neurobiology, 2013 - Elsevier
This review examines the role that respiratory plasticity has in the maintenance of breathing
stability during sleep in individuals with sleep apnea. The initial portion of the review …

[HTML][HTML] Identifying pathways modulating sleep duration: from genomics to transcriptomics

KV Allebrandt, M Teder-Laving, P Cusumano… - Scientific reports, 2017 - nature.com
Recognizing that insights into the modulation of sleep duration can emerge by exploring the
functional relationships among genes, we used this strategy to explore the genome-wide …

Intermittent hypoxia initiated plasticity in humans: a multipronged therapeutic approach to treat sleep apnea and overlapping co-morbidities

JH Mateika, D Komnenov - Experimental neurology, 2017 - Elsevier
Over the past three decades exposure to intermittent hypoxia (IH) has generally been
considered a stimulus associated with a number of detrimental outcomes. However, there is …

Sleep apnea research in animals. Past, present, and future

S Chopra, VY Polotsky, JC Jun - American journal of respiratory cell …, 2016 - atsjournals.org
Obstructive sleep apnea (OSA) is a common disorder that describes recurrent collapse of
the upper airway during sleep. Animal models have been pivotal to the understanding of …

Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives

P Lévy, JL Pépin, C Arnaud, R Tamisier… - European …, 2008 - Eur Respiratory Soc
There are three major types of sleep-disordered breathing (SDB) with respect to prevalence
and health consequences, ie obstructive sleep apnoea syndrome (OSAS), Cheyne–Stokes …

[HTML][HTML] A novel chip for cyclic stretch and intermittent hypoxia cell exposures mimicking obstructive sleep apnea

N Campillo, I Jorba, L Schaedel, B Casals… - Frontiers in …, 2016 - frontiersin.org
Intermittent hypoxia (IH), a hallmark of obstructive sleep apnea (OSA), plays a critical role in
the pathogenesis of OSA-associated morbidities, especially in the cardiovascular and …

The protective role of SOD1 overexpression in central mediation of bradycardia following chronic intermittent hypoxia in mice

J Chen, H Gu, RD Wurster… - American Journal of …, 2021 - journals.physiology.org
Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder that is associated with
many cardiovascular complications. Similar to OSA, chronic intermittent hypoxia (CIH)(a …

Genome-wide gene expression profiling in children with non-obese obstructive sleep apnea

A Khalyfa, OS Capdevila, MO Buazza, LD Serpero… - Sleep medicine, 2009 - Elsevier
BACKGROUND: Obstructive sleep apnea (OSA) is a multi-factorial and highly prevalent
disorder in which both genetic and environmental factors may be involved. If left untreated …

[HTML][HTML] Obstructive Sleep Apnea-Associated Intermittent Hypoxia-Induced Immune Responses in Males, Pregnancies, and Offspring

R Song, TL Baker, JJ Watters, S Kumar - International Journal of …, 2024 - mdpi.com
Obstructive sleep apnea (OSA), a respiratory sleep disorder associated with cardiovascular
diseases, is more prevalent in men. However, OSA occurrence in pregnant women rises to a …