Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives

P Lévy, JL Pépin, C Arnaud, R Tamisier… - European …, 2008 - Eur Respiratory Soc
There are three major types of sleep-disordered breathing (SDB) with respect to prevalence
and health consequences, ie obstructive sleep apnoea syndrome (OSAS), Cheyne–Stokes …

Adaptive exhaustion during prolonged intermittent hypoxia causes dysregulated skeletal muscle protein homeostasis

AH Attaway, A Bellar, S Mishra… - The Journal of …, 2023 - Wiley Online Library
Nocturnal hypoxaemia, which is common in chronic obstructive pulmonary disease (COPD)
patients, is associated with skeletal muscle loss or sarcopenia, which contributes to adverse …

A novel chip for cyclic stretch and intermittent hypoxia cell exposures mimicking obstructive sleep apnea

N Campillo, I Jorba, L Schaedel, B Casals… - Frontiers in …, 2016 - frontiersin.org
Intermittent hypoxia (IH), a hallmark of obstructive sleep apnea (OSA), plays a critical role in
the pathogenesis of OSA-associated morbidities, especially in the cardiovascular and …

The protective role of SOD1 overexpression in central mediation of bradycardia following chronic intermittent hypoxia in mice

J Chen, H Gu, RD Wurster… - American Journal of …, 2021 - journals.physiology.org
Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder that is associated with
many cardiovascular complications. Similar to OSA, chronic intermittent hypoxia (CIH)(a …

The discovery, validation, and function of hypoxia-related gene biomarkers for obstructive sleep apnea

X Wu, Z Pan, W Liu, S Zha, Y Song, Q Zhang… - Frontiers in …, 2022 - frontiersin.org
While there is emerging evidence that hypoxia critically contributes to the pathobiology of
obstructive sleep apnea (OSA), the diagnostic value of measuring hypoxia or its surrogates …

Genome-wide gene expression profiling in children with non-obese obstructive sleep apnea

A Khalyfa, OS Capdevila, MO Buazza, LD Serpero… - Sleep medicine, 2009 - Elsevier
BACKGROUND: Obstructive sleep apnea (OSA) is a multi-factorial and highly prevalent
disorder in which both genetic and environmental factors may be involved. If left untreated …

Effects of intermittent hypoxia on cytokine expression involved in insulin resistance

T Uchiyama, H Ota, C Ohbayashi… - International Journal of …, 2021 - mdpi.com
Sleep apnea syndrome (SAS) is a prevalent disorder characterized by recurrent apnea or
hypoxia episodes leading to intermittent hypoxia (IH) and arousals during sleep. Currently …

Obstructive Sleep Apnea-Associated Intermittent Hypoxia-Induced Immune Responses in Males, Pregnancies, and Offspring

R Song, TL Baker, JJ Watters, S Kumar - International Journal of …, 2024 - mdpi.com
Obstructive sleep apnea (OSA), a respiratory sleep disorder associated with cardiovascular
diseases, is more prevalent in men. However, OSA occurrence in pregnant women rises to a …

Mechanisms of acute and chronic blood pressure elevation in animal models of obstructive sleep apnea

CD Schaub, H Schneider… - LUNG BIOLOGY IN …, 2000 - api.taylorfrancis.com
Human obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular
morbidity and mortality (1–6). The existence of a direct link between the sleep and …

Obstructive sleep apnea, oxidative stress and cardiovascular disease: lessons from animal studies

R Dumitrascu, J Heitmann, W Seeger… - Oxidative medicine …, 2013 - Wiley Online Library
Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular (CV)
diseases such as arterial hypertension, heart failure, and stroke. Based on human research …