Culture of preimplantation embryos and its long-term effects on gene expression and phenotype

S Khosla, W Dean, W Reik, R Feil - Human reproduction update, 2001 - academic.oup.com
A growing number of medical, scientific and biotechnological procedures rely on culture of
mammalian preimplantation embryos. This review presents currently available data on …

Effect of incubation volume and embryo density on the development and viability of mouse embryos in vitro

M Lane, DK Gardner - Human reproduction, 1992 - academic.oup.com
The morphology, cleavage rate and viability of preimplantation embryos from random bred
Swiss mice were assessed after culture in different incubation volumes and embryo …

Effect of in vitro fertilization on gene expression and development of mouse preimplantation embryos

G Giritharan, S Talbi, A Donjacour… - …, 2007 - rep.bioscientifica.com
In vitro culture (IVC) of preimplantation mouse embryos is associated with changes in gene
expression. It is however, not known if the method of fertilization affects the global pattern of …

Suboptimal in vitro culture conditions: an epigenetic origin of long‐term health effects

R Fernández‐Gonzalez, MA Ramirez… - Molecular …, 2007 - Wiley Online Library
The foetal origins of adult diseases or Barker hypothesis suggests that there can be adverse
in uterus effects on the foetus that can lead to certain diseases in adults. Extending this …

Preimplantation embryo metabolism and culture systems: experience from domestic animals and clinical implications

VA Absalón-Medina, WR Butler, RO Gilbert - Journal of Assisted …, 2014 - Springer
Despite advantages of in vitro embryo production in many species, widespread use of this
technology is limited by generally lower developmental competence of in vitro derived …

Loss of genomic imprinting in mouse embryos with fast rates of preimplantation development in culture

BA Market Velker, MM Denomme… - Biology of …, 2012 - academic.oup.com
Currently, the stage of embryo development has been proposed as one of many criteria for
identifying healthy embryos in infertility clinics with the fastest embryos being highlighted as …

Development in vitro of preimplantation embryos from 55 mouse strains

O Suzuki, T Asano, Y Yamamoto… - Reproduction, fertility …, 1996 - CSIRO Publishing
Mouse pronuclear embryos were obtained by in vitro fertilization with oocytes of 55 strains of
immature females by gonadotrophin-induced ovulation and epididymal sperm of Slc: ICR …

Culture of preimplantation mouse embryos affects fetal development and the expression of imprinted genes

S Khosla, W Dean, D Brown, W Reik… - Biology of …, 2001 - academic.oup.com
Culture of preimplantation mammalian embryos and cells can influence their subsequent
growth and differentiation. Previously, we reported that culture of mouse embryonic stem …

Ex vivo early embryo development and effects on gene expression and imprinting

DK Gardner, M Lane - Reproduction, Fertility and Development, 2005 - CSIRO Publishing
The environment to which the mammalian embryo is exposed during the preimplantation
period of development has a profound effect on the physiology and viability of the …

Chemically defined media and the culture of mammalian preimplantation embryos: historical perspective and current issues

MC Summers, JD Biggers - Human reproduction update, 2003 - academic.oup.com
Considerable advances in media development for the culture of preimplantation mammalian
embryos have been made since mouse embryos were first cultured and successfully …