Background Due to unmet clinical needs for efficient drugs with a rapid onset of
antidepressant effects, we aimed to evaluate the efficacy of single-dose ketamine in different …

Among treatments currently assessed in major depression, ketamine, has been proposed of
great interest, especially because of its very rapid action. However, the time-course of the …

BackgroundThere is growing interest in glutamatergic agents in depression, particularly
ketamine, a glutamate N-methyl-d-aspartate (NMDA) receptor antagonist. We aimed to …

Objective The current meta‐analysis examines the effects of ketamine infusion on
depressive symptoms over time in major depressive disorder (MDD) and bipolar disorder …

BACKGROUND: Currently, no pharmacological treatments for bipolar depression exist that
exert rapid (within hours) antidepressant or antisuicidal effects. We previously reported that …

Background Ketamine appears to have a therapeutic role in certain mental disorders, most
notably unipolar major depressive disorder. However, its efficacy in bipolar depression is …

Background Ketamine is reported to have rapid antidepressant effects; however, there is
limited understanding of the time-course of ketamine effects beyond a single infusion. A …

Objective: Clinical trials demonstrated that ketamine exhibits rapid antidepressant efficacy
when administered in subanaesthetic dosages. We reviewed currently available literature …

Objective Given the significant disability, morbidity and mortality associated with depression,
the promising recent trials of ketamine highlight a novel intervention. A meta-analysis was …

Objective: Narrative review of the literature on the efficacy and safety of subanaesthetic
doses of ketamine for the treatment of depression. Method: Medline and PubMed databases …