Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs
Oligodeoxynucleotides (ODN) that contain unmethylated CpG dinucleotides trigger a strong
innate immune response in vertebrates. CpG ODN show promise as vaccine adjuvants, anti …
innate immune response in vertebrates. CpG ODN show promise as vaccine adjuvants, anti …
Immunoregulatory activity of CpG oligonucleotides in humans and nonhuman primates
D Verthelyi, DM Klinman - Clinical Immunology, 2003 - Elsevier
Oligodeoxynucleotides (ODN) containing CpG motifs mimic the ability of microbial DNA to
activate the innate immune system. The resultant response limits the early spread of …
activate the innate immune system. The resultant response limits the early spread of …
Use of CpG oligodeoxynucleotides as immune adjuvants
DM Klinman, D Currie, I Gursel… - Immunological …, 2004 - Wiley Online Library
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …
Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotide
Synthetic oligodeoxynucleotides (ODN) expressing “CpG motifs” show promise as immune
adjuvants, antiallergens, anticancer, and immunoprotective agents. Two structurally distinct …
adjuvants, antiallergens, anticancer, and immunoprotective agents. Two structurally distinct …
Strategies for enhancing the immunostimulatory effects of CpG oligodeoxynucleotides
Synthetic oligodeoxynucleotides (ODN) containing CpG sequences are recognized as a
“danger” signal by the immune system of mammals. As a consequence, CpG ODN stimulate …
“danger” signal by the immune system of mammals. As a consequence, CpG ODN stimulate …
Immunotherapeutic uses of CpG oligodeoxynucleotides
DM Klinman - Nature Reviews Immunology, 2004 - nature.com
Synthetic oligodeoxynucleotides (ODNs) that contain immunostimulatory CpG motifs trigger
an immunomodulatory cascade that involves B and T cells, natural killer cells and …
an immunomodulatory cascade that involves B and T cells, natural killer cells and …
CpG DNA as a vaccine adjuvant
DM Klinman - Expert review of vaccines, 2003 - Taylor & Francis
Synthetic oligodeoxynucleotides containing unmethylated CpG motifs act as immune
adjuvants, accelerating and boosting antigen-specific antibody responses by up to 500-fold …
adjuvants, accelerating and boosting antigen-specific antibody responses by up to 500-fold …
CpG RNA: identification of novel single-stranded RNA that stimulates human CD14+ CD11c+ monocytes
T Sugiyama, M Gursel, F Takeshita… - The Journal of …, 2005 - journals.aai.org
Synthetic immunostimulatory nucleic acids such as CpG DNA are being harnessed
therapeutically as vaccine adjuvants, anticancer or antiallergic agents. Efforts to identify …
therapeutically as vaccine adjuvants, anticancer or antiallergic agents. Efforts to identify …
CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases
DM Klinman, S Klaschik, T Sato, D Tross - Advanced drug delivery reviews, 2009 - Elsevier
Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs act as immune
adjuvants, accelerating and boosting antigen-specific immune responses. CpG motifs …
adjuvants, accelerating and boosting antigen-specific immune responses. CpG motifs …
Adjuvant activity of CpG oligodeoxynucleotides
DM Klinman - International reviews of immunology, 2006 - Taylor & Francis
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …