Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs

D Verthelyi, KJ Ishii, M Gursel, F Takeshita… - The Journal of …, 2001 - journals.aai.org
Oligodeoxynucleotides (ODN) that contain unmethylated CpG dinucleotides trigger a strong
innate immune response in vertebrates. CpG ODN show promise as vaccine adjuvants, anti …

Immunoregulatory activity of CpG oligonucleotides in humans and nonhuman primates

D Verthelyi, DM Klinman - Clinical Immunology, 2003 - Elsevier
Oligodeoxynucleotides (ODN) containing CpG motifs mimic the ability of microbial DNA to
activate the innate immune system. The resultant response limits the early spread of …

Use of CpG oligodeoxynucleotides as immune adjuvants

DM Klinman, D Currie, I Gursel… - Immunological …, 2004 - Wiley Online Library
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …

Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotide

M Gürsel, D Verthelyi, I Gürsel, KJ Ishii… - Journal of Leukocyte …, 2002 - academic.oup.com
Synthetic oligodeoxynucleotides (ODN) expressing “CpG motifs” show promise as immune
adjuvants, antiallergens, anticancer, and immunoprotective agents. Two structurally distinct …

Strategies for enhancing the immunostimulatory effects of CpG oligodeoxynucleotides

GK Mutwiri, AK Nichani, S Babiuk, LA Babiuk - Journal of controlled release, 2004 - Elsevier
Synthetic oligodeoxynucleotides (ODN) containing CpG sequences are recognized as a
“danger” signal by the immune system of mammals. As a consequence, CpG ODN stimulate …

Immunotherapeutic uses of CpG oligodeoxynucleotides

DM Klinman - Nature Reviews Immunology, 2004 - nature.com
Synthetic oligodeoxynucleotides (ODNs) that contain immunostimulatory CpG motifs trigger
an immunomodulatory cascade that involves B and T cells, natural killer cells and …

CpG DNA as a vaccine adjuvant

DM Klinman - Expert review of vaccines, 2003 - Taylor & Francis
Synthetic oligodeoxynucleotides containing unmethylated CpG motifs act as immune
adjuvants, accelerating and boosting antigen-specific antibody responses by up to 500-fold …

CpG RNA: identification of novel single-stranded RNA that stimulates human CD14+ CD11c+ monocytes

T Sugiyama, M Gursel, F Takeshita… - The Journal of …, 2005 - journals.aai.org
Synthetic immunostimulatory nucleic acids such as CpG DNA are being harnessed
therapeutically as vaccine adjuvants, anticancer or antiallergic agents. Efforts to identify …

CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases

DM Klinman, S Klaschik, T Sato, D Tross - Advanced drug delivery reviews, 2009 - Elsevier
Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs act as immune
adjuvants, accelerating and boosting antigen-specific immune responses. CpG motifs …

Adjuvant activity of CpG oligodeoxynucleotides

DM Klinman - International reviews of immunology, 2006 - Taylor & Francis
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …