The currently available chemotherapeutic regimens against gastric cancer are not very
effective, leading to high recurrence and poor survival. Resveratrol is a naturally occurring …

Sirtuins are NAD+ dependent deacetylases and/or ADP-ribosyl transferases active on
histone and non-histone substrates. The first sirtuin was discovered as a transcriptional …

Human liposarcoma is the most common soft tissue sarcoma. There is no effective therapy
so far except for surgery. In this study, we report for the first time that curcumin induces …

Inflammation is one of main mechanisms of autoimmune disorders and a common feature of
most diseases. Appropriate suppression of inflammation is a key resolution to treat the …

Glioblastomas, the most common form of primary brain tumors, are the fourth cause of death
by cancer in adults. Increasing evidences suggest that glioblastoma resistance to existing …

Objective SIRT1 is known to inhibit apoptosis and to promote survival of various types of
cells. However, the roles of SIRT1 in apoptosis of human chondrocytes have never been …

Numerous studies have shown that resveratrol can induce apoptosis in cancer cells. Trans-
3, 5, 4-trimethoxystilbene (TMS), a novel derivative of resveratrol, is a more potent …

Malignant glioma is one of the most common types of primary malignancies in the human
central nervous system. Temozolomide (TMZ) is the most commonly used drug in clinical …

Abstract Sirtuin 6 (SIRT6) is a member of the mammalian NAD+‑dependent deacetylase
sirtuin family that acts to maintain genomic stability and to repress genes. SIRT6 has recently …

Abstract Resveratrol (RSV), a plant‐derived stilbene, induces cell death in Hodgkin
lymphoma (HL)‐derived L‐428 cells in a dose‐dependent manner (IC50= 27 μM, trypan …