[HTML][HTML] Sirt1 is required for resveratrol-mediated chemopreventive effects in colorectal cancer cells
C Buhrmann, P Shayan, B Popper, A Goel… - Nutrients, 2016 - mdpi.com
Sirt1 is a NAD+-dependent protein-modifying enzyme involved in regulating gene
expression, DNA damage repair, metabolism and survival, as well as acts as an important …
expression, DNA damage repair, metabolism and survival, as well as acts as an important …
[HTML][HTML] Inhibition of SIRT6 potentiates the anti-tumor effect of doxorubicin through suppression of the DNA damage repair pathway in osteosarcoma
Background SIRT6 has diverse roles in cells, and the role of SIRT6 in tumorigenesis is
controversial. Considering the role of SIRT6 as an inducer of DNA damage repair, it might …
controversial. Considering the role of SIRT6 as an inducer of DNA damage repair, it might …
[HTML][HTML] Sirtuin 7 promotes non‑small cell lung cancer progression by facilitating G1/S phase and epithelial‑mesenchymal transition and activating AKT and ERK1/2 …
Y Zhao, X Ye, R Chen, Q Gao, D Zhao… - Oncology …, 2020 - spandidos-publications.com
Increasing evidence has indicated the roles of sirtuin 7 (SIRT7) in numerous human
cancers. However, the effects and the clinical significance of SIRT7 in human lung cancer is …
cancers. However, the effects and the clinical significance of SIRT7 in human lung cancer is …
[HTML][HTML] Resveratrol induces human keratinocyte damage via the activation of class III histone deacetylase, Sirt1
JH Lee, JS Kim, SY Park, YJ Lee - Oncology reports, 2016 - spandidos-publications.com
Human skin diseases are various and induce chronic inflammatory disorders, including
psoriasis, atopic dermatitis and certain forms of ichthyosis. Psoriasis is a chronic …
psoriasis, atopic dermatitis and certain forms of ichthyosis. Psoriasis is a chronic …
[HTML][HTML] Sirtuin1 activator SRT2183 suppresses glioma cell growth involving activation of endoplasmic reticulum stress pathway
T Ye, L Wei, J Shi, K Jiang, H Xu, L Hu, L Kong… - BMC cancer, 2019 - Springer
Background Glioblastoma (GBM) is an extremely deadly form of brain cancer with limited
treatment options and thus novel therapeutic modalities are necessary. Histone deacetylase …
treatment options and thus novel therapeutic modalities are necessary. Histone deacetylase …
SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-κB pathway
G Li, Z Xia, Y Liu, F Meng, X Wu, Y Fang… - Bioscience …, 2018 - portlandpress.com
Rheumatoid arthritis (RA) is an autoimmune disease of the joints characterized by synovial
hyperplasia and chronic inflammation. Fibroblast-like synoviocytes (FLS) play a central role …
hyperplasia and chronic inflammation. Fibroblast-like synoviocytes (FLS) play a central role …
Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation
JN Lin, VCH Lin, KM Rau, PC Shieh… - Journal of agricultural …, 2010 - ACS Publications
Resveratrol functions as an agonist for estrogen receptor (ER)-mediated transcription.
However, other researchers have reported that resveratrol decreases proliferation of breast …
However, other researchers have reported that resveratrol decreases proliferation of breast …
[HTML][HTML] In vitro comparative studies of resveratrol and triacetylresveratrol on cell proliferation, apoptosis, and STAT3 and NFκB signaling in pancreatic cancer cells
Resveratrol (RES) has been studied extensively as an anticancer agent. However, the
anticancer effects of triacetylresveratrol (TRES, an acetylated analog of RES) which has …
anticancer effects of triacetylresveratrol (TRES, an acetylated analog of RES) which has …
75‐kd sirtuin 1 blocks tumor necrosis factor α–mediated apoptosis in human osteoarthritic chondrocytes
H Oppenheimer, O Gabay, H Meir, A Haze… - Arthritis & …, 2012 - Wiley Online Library
Abstract Objective Sirtuin 1 (SirT1) has been implicated in the regulation of human cartilage
homeostasis and chondrocyte survival. Exposing human osteoarthritic (OA) chondrocytes to …
homeostasis and chondrocyte survival. Exposing human osteoarthritic (OA) chondrocytes to …
[HTML][HTML] SIRT7 suppresses the epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis by promoting SMAD4 deacetylation
W Li, D Zhu, S Qin - Journal of Experimental & Clinical Cancer Research, 2018 - Springer
Background Oral squamous cell carcinoma (OSCC) is one of the most common
malignancies and has a poor prognosis. The epithelial-to-mesenchymal transition (EMT) is …
malignancies and has a poor prognosis. The epithelial-to-mesenchymal transition (EMT) is …