Chondrosarcoma is a soft tissue sarcoma with a poor prognosis that is unresponsive to
conventional chemotherapy. Surgical treatment leads to severe disability with high rates of …

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation
and destruction of synovial joints. The function of sirtuin (SIRT) 1 in RA is inconclusive. In …

Background Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths
worldwide. The only drug currently approved for clinical use in the treatment of advanced …

The aim of our study was to evaluate if Sirt6, a NAD+ dependent histone deacetylase, plays
a protective role in cartilage degeneration by suppressing cellular senescence and …

Nephrotoxicity is one of the important dose-limiting factors during cisplatin treatment. There
is a growing body of evidence that activation of p53 has a critical role in cisplatin-induced …

Abstract Sirtuin 6 (SIRT6) is a NAD-dependent deacetylase involved in lifespan regulation.
To evaluate the effect of SIRT6 on osteogenesis, rat bone marrow mesenchymal stem cells …

Resveratrol, a polyphenol found in fruits, has been demonstrated to activate Sir2. Though
many studies have demonstrated that resveratrol can activate SIRT1, whether it has effect on …

Sirtuin 3 (SIRT3) is the major mitochondria deacetylase and regulates ROS levels by
targeting several key proteins, such as those involved in mitochondrial function and …

Abstract Sirtuin 1 (SIRT1) is a class III histone/protein deacetylase, and its activation status
has been well documented to have physiologic benefits in human health. However, the …

Abstract Purpose Sirtuin 1 (SIRT1) comprises a major anti-aging longevity factor with
multiple protective effects on chondrocyte homeostasis. Previous studies have reported that …