The aim of our study was to evaluate if Sirt6, a NAD+ dependent histone deacetylase, plays
a protective role in cartilage degeneration by suppressing cellular senescence and …

Nephrotoxicity is one of the important dose-limiting factors during cisplatin treatment. There
is a growing body of evidence that activation of p53 has a critical role in cisplatin-induced …

Abstract Sirtuin 6 (SIRT6) is a NAD-dependent deacetylase involved in lifespan regulation.
To evaluate the effect of SIRT6 on osteogenesis, rat bone marrow mesenchymal stem cells …

Resveratrol, a polyphenol found in fruits, has been demonstrated to activate Sir2. Though
many studies have demonstrated that resveratrol can activate SIRT1, whether it has effect on …

Abstract Sirtuin 1 (SIRT1) is a class III histone/protein deacetylase, and its activation status
has been well documented to have physiologic benefits in human health. However, the …

Abstract Purpose Sirtuin 1 (SIRT1) comprises a major anti-aging longevity factor with
multiple protective effects on chondrocyte homeostasis. Previous studies have reported that …

Resveratrol (RES), a polyphenolic compound present in grapes and red wine, has potential
anticancer properties. The present study aimed to examine the effects of resveratrol and its …

Objective The aim of this study is to investigate the role of Sirtuin1 (Sirt1) in the regulation of
autophagy for human osteoarthritis (OA) chondrocytes. Design All cartilage samples were …

Sirtuin 3 (SIRT3) is the major mitochondria deacetylase and regulates ROS levels by
targeting several key proteins, such as those involved in mitochondrial function and …

Abstract Background Sirtuin-7 (SIRT7) is associated with the maintenance of tumorigenesis.
However, its functional roles and oncogenic mechanisms in prostate cancer (PCa) are …