Abstract The mitochondrial sirtuin 3 (SIRT3) is involved in suppressing the onset of multiple
pathologies, including cardiovascular disease, fatty liver, age-related hearing loss, and …

Abstract Sirtuin 1 (SIRT1), originally identified as a longevity gene, is induced by caloric
restriction, and regulates various cellular functions including DNA repair, cell survival and …

SIRT7 is a member of the sirtuin family of proteins that are known to be associated with
tumor development. However, the functional roles and molecular mechanisms underlying …

Mitochondrial dysfunction is an important contributor to the development of osteoarthritis
(OA). Sirtuin 3 (SIRT3) regulates diverse mitochondrial proteins to maintain mitochondrial …

Abstract Sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide-dependent deacetylase,
epigenetically regulates various cell metabolisms, including inflammation, tumorigenesis …

Sirtuins (SIRTs), which are nicotinamide adenine dinucleotide-dependent class III histone
deacetylases, regulate cell division, survival, and senescence. Although sirtinol, a synthetic …

Abstract Sirtuin-1 (Sirt-1), an NAD-dependent deacetylase, promotes tumorigenesis in
glioma; however, whether the Sirt-1 specific inhibitor, EX527 exerts antitumor effects and the …

Mutation of the p53 tumor suppressor frequently occurs in lung cancer, and can be as high
as 75‑90% in small‑cell lung cancer. Mutant p53 (mtp53) can inhibit the wild‑type p53 …

Arthritis is a common autoimmune disease that is associated with progressive disability,
systemic complications and early death. However, the underling mechanisms of arthritis are …

The sirtuins (SIRTs) are a family of nicotinamide-adenine dinucleotide (NAD)+‑dependent
protein deacetylases. SIRT4 is a mitochondrial NAD+‑dependent adenosine diphsophate …