Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cells

H Sell, J Laurencikiene, A Taube, K Eckardt… - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE Chemerin is an adipokine that affects adipogenesis and glucose homeostasis
in adipocytes and increases with BMI in humans. This study was aimed at investigating the …

Expression of human chemerin induces insulin resistance in the skeletal muscle but does not affect weight, lipid levels, and atherosclerosis in LDL receptor knockout …

M Becker, K Rabe, C Lebherz, J Zugwurst, B Göke… - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE Chemerin is a recently discovered hepatoadipokine that regulates adipocyte
differentiation as well as chemotaxis and activation of dendritic cells and macrophages …

Effects of weight loss and exercise on chemerin serum concentrations and adipose tissue expression in human obesity

R Chakaroun, M Raschpichler, N Klöting, A Oberbach… - Metabolism, 2012 - Elsevier
Chemerin is a chemoattractant adipokine that regulates adipogenesis and may induce
insulin resistance. Chemerin serum concentrations are elevated in obese, insulin-resistant …

Chemerin exacerbates glucose intolerance in mouse models of obesity and diabetes

MC Ernst, M Issa, KB Goralski, CJ Sinal - Endocrinology, 2010 - academic.oup.com
Obesity, characterized by an excess of adipose tissue, is an established risk factor for
cardiovascular disease and type 2 diabetes. Different mechanisms linking obesity with these …

[HTML][HTML] Differential patterns of serum concentration and adipose tissue expression of chemerin in obesity: adipose depot specificity and gender dimorphism

AA Alfadda, RM Sallam, MA Chishti, AS Moustafa… - Molecules and cells, 2012 - Elsevier
Chemerin, a recognized chemoattractant, is expressed in adipose tissue and plays a role in
adipocytes differentiation and metabolism. Gender-and adipose tissue-specific differences …

Chemerin: a multifaceted adipokine involved in metabolic disorders

G Helfer, QF Wu - Journal of Endocrinology, 2018 - joe.bioscientifica.com
Metabolic syndrome is a global public health problem and predisposes individuals to
obesity, diabetes and cardiovascular disease. Although the underlying mechanisms remain …

[HTML][HTML] Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes

M Takahashi, Y Takahashi, K Takahashi, FN Zolotaryov… - FEBS letters, 2008 - Elsevier
To explore a novel adipokine, we screened adipocyte differentiation-related gene and found
that TIG2/chemerin was strongly induced during the adipocyte differentiation. Chemerin was …

Chemerin is a novel adipokine associated with obesity and metabolic syndrome

K Bozaoglu, K Bolton, J McMillan, P Zimmet… - …, 2007 - academic.oup.com
Soluble protein hormones are key regulators of a number of metabolic processes, including
food intake and insulin sensitivity. We have used a signal sequence trap to identify genes …

Interleukin-1ß induces the novel adipokine chemerin in adipocytes in vitro

S Kralisch, S Weise, G Sommer, J Lipfert, U Lossner… - Regulatory peptides, 2009 - Elsevier
Chemerin has recently been characterized as a novel adipokine playing a crucial role in
adipocyte differentiation and insulin signalling. In the current study, the impact of insulin …

Serum chemerin levels vary with time of day and are modified by obesity and tumor necrosis factor-α

SD Parlee, MC Ernst, S Muruganandan, CJ Sinal… - …, 2010 - academic.oup.com
Chemerin is an adipokine with important regulatory roles in adipogenesis. In humans, serum
total chemerin (ie prochemerin plus chemerin) levels are positively associated with body …