microRNA therapeutics in cancer—an emerging concept

MY Shah, A Ferrajoli, AK Sood, G Lopez-Berestein… - …, 2016 - thelancet.com
MicroRNAs (miRNAs) are an evolutionarily conserved class of small, regulatory non-coding
RNAs that negatively regulate protein coding gene and other non-coding transcripts …

MicroRNAs as therapeutic targets in human cancers

MY Shah, GA Calin - Wiley Interdisciplinary Reviews: RNA, 2014 - Wiley Online Library
MicroRNAs (miRNAs) are evolutionarily conserved, small, regulatory RNAs that negatively
regulate gene expression. Extensive research in the last decade has implicated miRNAs as …

MicroRNAs: novel players in cancer diagnosis and therapies

AL Oom, BA Humphries, C Yang - BioMed research …, 2014 - Wiley Online Library
First discovered in 1993, microRNAs (miRNAs) have been one of the hottest research areas
over the past two decades. Oftentimes, miRNAs levels are found to be dysregulated in …

Therapeutic targeting of microRNAs in cancer: future perspectives

L Tutar, E Tutar, A Özgür, Y Tutar - Drug development research, 2015 - Wiley Online Library
ABSTRACT Preclinical Research The discovery of microRNAs (miRNAs) and their link with
cancer has opened a new era in cancer therapeutics. Approximately, 18− 24 nucleotides …

[HTML][HTML] MicroRNA-based cancer therapeutics: big hope from small RNAs

A Bhardwaj, S Singh, AP Singh - Molecular and cellular …, 2010 - ncbi.nlm.nih.gov
Tremendous progress has been made during the last few years in identification of novel
tumor-associated microRNAs and experimental validation of their cancer relevant gene …

Therapeutic microRNA strategies in human cancer

C Li, Y Feng, G Coukos, L Zhang - The AAPS journal, 2009 - Springer
Abstract MicroRNAs (miRNAs) are~ 22 nucleotide long, noncoding, endogenous RNA
molecules which exert their functions by base pairing with messenger RNAs (mRNAs) …

Therapeutic microRNAs in human cancer

G Ors-Kumoglu, S Gulce-Iz, C Biray-Avci - Cytotechnology, 2019 - Springer
MicroRNAs (miRNAs) are RNA molecules at about 22 nucleotide in length that are non-
coding, which regulate gene expression in the post-transcriptional level by performing …

Recent trends in targeting miRNAs for cancer therapy

V Shah, J Shah - Journal of Pharmacy and Pharmacology, 2020 - academic.oup.com
Objectives MicroRNAs (miRNAs) are a type of small noncoding RNA employed by the cells
for gene regulation. A single miRNA, typically 22 nucleotides in length, can regulate the …

Targeting microRNAs in cancer: rationale, strategies and challenges

R Garzon, G Marcucci, CM Croce - Nature reviews Drug discovery, 2010 - nature.com
MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that regulate
gene expression. Early studies have shown that miRNA expression is deregulated in cancer …

microRNAs as cancer therapeutics: A step closer to clinical application

TC Ivkovic, G Voss, H Cornella, Y Ceder - Cancer letters, 2017 - Elsevier
During the last decades, basic and translational research has enabled great improvements
in the clinical management of cancer. However, scarcity of complete remission and many …