The etiologies of neurodegenerative diseases may be diverse; however, a common
pathological denominator is the formation of aberrant protein conformers and the occurrence …

Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and prion diseases are …

A key molecular pathway implicated in diverse neurodegenerative diseases is the
misfolding, aggregation, and accumulation of proteins in the brain. Compelling evidence …

The protein aggregation that occurs in neurodegenerative diseases is classically thought to
occur as an undesirable, nonfunctional byproduct of protein misfolding. This model contrasts …

Several neurodegenerative disorders, such as Alzheimer's and Parkinson's disease, are
characterized by prominent loss of synapses and neurons associated with the presence of …

Abstract α-Synuclein (α-Syn) is an aggregation-prone protein whose accumulation in Lewy
bodies leads to neurodegenerative diseases like Parkinson's disease (PD). Calcium plays a …

Formation of membrane-less organelles via liquid-liquid phase separation is one way cells
meet the biological requirement for spatiotemporal regulation of cellular components and …

Fibrillar protein aggregates are a hallmark of a range of human disorders, from prion
diseases to dementias, but are also encountered in several functional contexts. Yet, the …

Aging is the most important risk factor for neurodegenerative diseases associated with
pathological protein aggregation such as Alzheimer's disease. Although aging is an …

Aggregation of the microtubule-associated protein tau plays a major role in Alzheimer's
disease and several other neurodegenerative disorders. An exciting recent development is …