The two faces of protein misfolding: gain‐and loss‐of‐function in neurodegenerative diseases
KF Winklhofer, J Tatzelt, C Haass - The EMBO journal, 2008 - embopress.org
The etiologies of neurodegenerative diseases may be diverse; however, a common
pathological denominator is the formation of aberrant protein conformers and the occurrence …
pathological denominator is the formation of aberrant protein conformers and the occurrence …
Protein aggregation and neurodegenerative disease
CA Ross, MA Poirier - Nature medicine, 2004 - nature.com
Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and prion diseases are …
Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and prion diseases are …
Protein misfolding and neurodegeneration
C Soto, LD Estrada - Archives of neurology, 2008 - jamanetwork.com
A key molecular pathway implicated in diverse neurodegenerative diseases is the
misfolding, aggregation, and accumulation of proteins in the brain. Compelling evidence …
misfolding, aggregation, and accumulation of proteins in the brain. Compelling evidence …
Regulated protein aggregation: stress granules and neurodegeneration
B Wolozin - Molecular neurodegeneration, 2012 - Springer
The protein aggregation that occurs in neurodegenerative diseases is classically thought to
occur as an undesirable, nonfunctional byproduct of protein misfolding. This model contrasts …
occur as an undesirable, nonfunctional byproduct of protein misfolding. This model contrasts …
Physico-pathologic mechanisms involved in neurodegeneration: misfolded protein-plasma membrane interactions
Several neurodegenerative disorders, such as Alzheimer's and Parkinson's disease, are
characterized by prominent loss of synapses and neurons associated with the presence of …
characterized by prominent loss of synapses and neurons associated with the presence of …
Calcium promotes α-synuclein liquid-liquid phase separation to accelerate amyloid aggregation
S Huang, B Xu, Y Liu - Biochemical and biophysical research …, 2022 - Elsevier
Abstract α-Synuclein (α-Syn) is an aggregation-prone protein whose accumulation in Lewy
bodies leads to neurodegenerative diseases like Parkinson's disease (PD). Calcium plays a …
bodies leads to neurodegenerative diseases like Parkinson's disease (PD). Calcium plays a …
Liquid-liquid phase separation induces pathogenic tau conformations in vitro
Formation of membrane-less organelles via liquid-liquid phase separation is one way cells
meet the biological requirement for spatiotemporal regulation of cellular components and …
meet the biological requirement for spatiotemporal regulation of cellular components and …
Uncovering the universality of self-replication in protein aggregation and its link to disease
Fibrillar protein aggregates are a hallmark of a range of human disorders, from prion
diseases to dementias, but are also encountered in several functional contexts. Yet, the …
diseases to dementias, but are also encountered in several functional contexts. Yet, the …
Age-dependent protein aggregation initiates amyloid-β aggregation
N Groh, A Bühler, C Huang, KW Li… - Frontiers in aging …, 2017 - frontiersin.org
Aging is the most important risk factor for neurodegenerative diseases associated with
pathological protein aggregation such as Alzheimer's disease. Although aging is an …
pathological protein aggregation such as Alzheimer's disease. Although aging is an …
Tau liquid–liquid phase separation in neurodegenerative diseases
S Boyko, WK Surewicz - Trends in cell biology, 2022 - cell.com
Aggregation of the microtubule-associated protein tau plays a major role in Alzheimer's
disease and several other neurodegenerative disorders. An exciting recent development is …
disease and several other neurodegenerative disorders. An exciting recent development is …