Marfan syndrome (MS) is of the most common connective tissue disorders. Although most
patients have mutations in the fibrillin-1 gene (FBN1) and more than 1,700 mutations have …

Background: Marfan Syndrome (MFS) has been associated with increased aortic stiffness
and left ventricular dysfunction. The latter may be due to the underlying genotype and/or …

Background—The cardiovascular complications of Marfan syndrome arise due to alterations
in the structural and functional properties of fibrillin, a constituent of vascular connective …

Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the FBN1
gene, which encodes fibrillin-1, a protein essential for the formation and stabilization of …

Objective: Marfan syndrome (MFS) is an autosomal dominant genetic disorder characterized
by aortic root dilation and dissection and an abnormal fibrillin-1 synthesis. In this …

Marfan syndrome (MFS) is a connective tissue disorder characterized by typical skeletal,
ocular, and cardiovascular features. The latter include aortic root dilatation, with associated …

Background—In patients with Marfan syndrome (MFS), brachial pulse pressure (PP) has
been recognized as a risk factor for aortic dilatation, leading to aortic dissection, the main …

Eur J Clin Invest 2012 Abstract Background Aortic dilatation is the main therapeutic target in
patients with Marfan syndrome. Standard treatment with a β‐blocker may not lower central …

Background Marfan syndrome (MFS) is a pleiotropic genetic disorder with major features in
cardiovascular, ocular and skeletal systems, associated with large clinical variability …

Background The major clinical problem of Marfan syndrome (MFS) is the aortic root
aneurysm, with risk of dissection when the root diameter approximates 5 cm. In MFS, a key …