The aim of this study was to determine whether neurokinin B (NKB) or specific agonists of
tachykinin NK3 receptors,[MePhe7] NKB and senktide, were able to induce airway …

This study has examined the abilities of (+/-)-CP96345 and (+/-)-SR48968, nonpeptide
antagonists selective for the tachykinin NK1 and NK2 receptors, respectively, to block …

Tachykinins are potent bronchoconstrictors. Here we have used novel highly selective
agonists and antagonists to characterize tachykinin receptors mediating bronchoconstriction …

1 NK1 and NK2 receptors have been characterized in guinea‐pig lung membrane
preparations by use of [125I‐Tyr8]‐substance P and [125I]‐neurokinin A binding assays in …

1 In many species, both NK1 and NK2 tachykinin receptors appear to be important in
mediating the contraction of airway smooth muscle. We have examined the distribution and …

Several recent observations suggest that tachykinins, such as substance P and neurokinin
A, might be involved in the pathogenesis of bronchopulmonary alterations. Progress in …

Neurokinin A (NKA) is the primary bronchoconstrictor tachykinin in the lungs of several
species, including humans and has been implicated as an important mediator of …

Tachykinins, in particular neurokinin A and substance P, produce a number of airway effects
which may contribute to respiratory diseases such as asthma. We examined the ability of …

The potent contractile responses of guinea-pig airways to neurokinin A (NKA) and
neuropeptide γ (NPγ) are thought to be mediated by NK-2 receptors. However, NK-2 binding …

Tachykinins produce concentration-dependent contraction of the human isolated bronchus
by stimulation of receptors that belong to the NK2 type. The aim of this study was to …