Lack of resistance to integrase inhibitors among antiretroviral-naive subjects with primary HIV-1 infection, 2007–2013
JD Stekler, J McKernan, R Milne, KA Tapia… - 2015 - journals.sagepub.com
Background US guidelines recommend genotyping for persons newly diagnosed with HIV
infection to identify transmitted drug resistance mutations associated with decreased …
infection to identify transmitted drug resistance mutations associated with decreased …
Impact of HIV-1 integrase L74F and V75I mutations in a clinical isolate on resistance to second-generation integrase strand transfer inhibitors
A Hachiya, KA Kirby, Y Ido, U Shigemi… - Antimicrobial Agents …, 2017 - Am Soc Microbiol
ABSTRACT A novel HIV-1 integrase mutation pattern, L74F V75I, which conferred
resistance to first-generation integrase strand transfer inhibitors (INSTIs), was identified in a …
resistance to first-generation integrase strand transfer inhibitors (INSTIs), was identified in a …
HIV-1 genetic diversity and natural polymorphisms of the integrase gene in integrase inhibitor-naive patients in Harare, Zimbabwe
Previously used as part of salvage therapy, integrase strand transfer inhibitors (INSTIs) have
become part of the preferred antiretroviral therapy (ART) first-line regimen in most low-to …
become part of the preferred antiretroviral therapy (ART) first-line regimen in most low-to …
Prevalence of resistance mutations associated with integrase inhibitors in therapy-naive HIV-positive patients in Baoding, Hebei province, China
W Fan, X Wang, Y Zhang, J Meng, M Su, X Yang… - Frontiers in …, 2022 - frontiersin.org
Antiretroviral therapy (ART) regimens containing integrase strand transfer inhibitors (INSTIs)
are the recommended treatment for human immunodeficiency virus type 1 (HIV-1)-infected …
are the recommended treatment for human immunodeficiency virus type 1 (HIV-1)-infected …
Absence of integrase inhibitor-associated resistance among antiretroviral therapy-naïve HIV-1-infected adults in Guangdong Province, China, in 2018
Y Lan, L Li, W Chen, X Deng, J Li, Q Fan… - Infection and Drug …, 2020 - Taylor & Francis
Background Antiretroviral therapy (ART) containing an integrase strand transfer inhibitor
(INSTI) plus two nucleoside reverse-transcriptase inhibitors has been recommended as a …
(INSTI) plus two nucleoside reverse-transcriptase inhibitors has been recommended as a …
Integrase inhibitor (INI) genotypic resistance in treatment-naive and raltegravir-experienced patients infected with diverse HIV-1 clades
T Doyle, DT Dunn… - Journal of …, 2015 - academic.oup.com
Objectives The aim of this study was to characterize the prevalence and patterns of
genotypic integrase inhibitor (INI) resistance in relation to HIV-1 clade. Methods The cohort …
genotypic integrase inhibitor (INI) resistance in relation to HIV-1 clade. Methods The cohort …
Factors associated with the emergence of integrase resistance mutations in patients failing dual or triple integrase inhibitor-based regimens in a French national …
AG Marcelin, C Charpentier, P Bellecave… - Journal of …, 2021 - academic.oup.com
Abstract Background Successful 2-drug regimens (2DRs) for HIV were made possible by the
availability of drugs combining potency and tolerability with a high genetic barrier to …
availability of drugs combining potency and tolerability with a high genetic barrier to …
HIV-1 genetic diversity and transmitted drug resistance to integrase strand transfer inhibitors among recently diagnosed adults in Porto Alegre, South Brazil
CC Nunes, A Sita, L Mallmann… - Journal of …, 2022 - academic.oup.com
Objectives The HIV-1 genetic diversity and the presence of transmitted drug resistance
mutations (TDRMs) against integrase strand transfer inhibitors (INSTIs) were assessed …
mutations (TDRMs) against integrase strand transfer inhibitors (INSTIs) were assessed …
Successful prevention of transmission of integrase resistance in the Swiss HIV Cohort Study
AU Scherrer, WL Yang, RD Kouyos… - The Journal of …, 2016 - academic.oup.com
The prevalence of integrase strand transfer inhibitor (INSTI)–transmitted drug resistance
(TDR) may increase with the increasing use of INSTIs. We analyzed the prevalence of INSTI …
(TDR) may increase with the increasing use of INSTIs. We analyzed the prevalence of INSTI …
Prevalence and clinical impact of minority resistant variants in patients failing an integrase inhibitor-based regimen by ultra-deep sequencing
Background Integrase strand transfer inhibitors (INSTIs) are recommended by international
guidelines as first-line therapy in antiretroviral-naive and-experienced HIV-1-infected …
guidelines as first-line therapy in antiretroviral-naive and-experienced HIV-1-infected …