Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats

J Lee, W Duan, JM Long, DK Ingram… - Journal of Molecular …, 2000 - Springer
The adult brain contains neural stem cells that are capable of proliferating, differentiating
into neurons or glia, and then either surviving or dying. This process of neural-cell …

Evidence that brain‐derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the …

J Lee, W Duan, MP Mattson - Journal of neurochemistry, 2002 - Wiley Online Library
To determine the role of brain‐derived neurotrophic factor (BDNF) in the enhancement of
hippocampal neurogenesis resulting from dietary restriction (DR), heterozygous BDNF …

Dietary restriction stimulates BDNF production in the brain and thereby protects neurons against excitotoxic injury

W Duan, JW Lee, ZH Guo, MP Mattson - Journal of Molecular …, 2001 - Springer
Dietary restriction (DR) increases the lifespan of rodents and increases their resistance to
several different age-related diseases including cancer and diabetes. Beneficial effects of …

Brain‐derived neurotrophic factor mediates an excitoprotective effect of dietary restriction in mice

W Duan, ZH Guo, MP Mattson - Journal of neurochemistry, 2001 - Wiley Online Library
Dietary restriction (DR; reduced calorie intake) increases the lifespan of rodents and
increases their resistance to cancer, diabetes and other age‐related diseases. DR also …

Brain‐derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment

C Rossi, A Angelucci, L Costantin… - European Journal of …, 2006 - Wiley Online Library
Neurogenesis continues to occur in the adult mammalian hippocampus and is regulated by
both genetic and environmental factors. It is known that exposure to an enriched …

Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice

J Lee, KB Seroogy, MP Mattson - Journal of neurochemistry, 2002 - Wiley Online Library
The adult brain contains small populations of neural precursor cells (NPC) that can give rise
to new neurons and glia, and may play important roles in learning and memory, and …

A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning

R Molteni, RJ Barnard, Z Ying, CK Roberts… - Neuroscience, 2002 - Elsevier
We have investigated a potential mechanism by which a diet, similar in composition to the
typical diet of most industrialized western societies rich in saturated fat and refined sugar …

Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth

S Rauskolb, M Zagrebelsky, A Dreznjak… - Journal of …, 2010 - Soc Neuroscience
Although brain-derived neurotrophic factor (BDNF) is linked with an increasing number of
conditions causing brain dysfunction, its role in the postnatal CNS has remained difficult to …

Essential role of brain-derived neurotrophic factor in adult hippocampal function

LM Monteggia, M Barrot, CM Powell… - Proceedings of the …, 2004 - National Acad Sciences
Brain-derived neurotrophic factor (BDNF) regulates neuronal development and function.
However, it has been difficult to discern its role in the adult brain in influencing complex …

Learning upregulates brain-derived neurotrophic factor messenger ribonucleic acid: a mechanism to facilitate encoding and circuit maintenance?

JP Kesslak, V So, J Choi, CW Cotman… - Behavioral …, 1998 - psycnet.apa.org
Brain-derived neurotrophic factor (BDNF) promotes neuron survival, enhances sprouting,
protects neurons against insult, and may be involved in several aspects of learning and …