Cannabinoid receptor ligands: clinical and neuropharmacological considerations, relevant to future drug discovery and development

RG Pertwee - Expert opinion on investigational drugs, 2000 - Taylor & Francis
This review highlights some important advances that have taken place in cannabinoid
research over the last four years. It focuses on novel ligands that are of interest either as …

Pharmacology of cannabinoid CB1 and CB2 receptors

RG Pertwee - Pharmacology & therapeutics, 1997 - Elsevier
There are at least two types of cannabinoid receptors, CB1 and CB2, both coupled to G-
proteins. CB1 receptors are present in the central nervous system and CB1 and CB2 …

Receptors and channels targeted by synthetic cannabinoid receptor agonists and antagonists

RG Pertwee - Current medicinal chemistry, 2010 - ingentaconnect.com
It is widely accepted that non-endogenous compounds that target CB1 and/or CB2 receptors
possess therapeutic potential for the clinical management of an ever growing number of …

Neuropharmacology and therapeutic potential of cannabinoids

RG Pertwee - Addiction biology, 2000 - Wiley Online Library
Mammalian tissues contain at least two types of cannabinoid receptor, CB 1, found mainly
on neurones and CB 2, found mainly in immune cells. Endogenous ligands for these …

Emerging strategies for exploiting cannabinoid receptor agonists as medicines

RG Pertwee - British journal of pharmacology, 2009 - Wiley Online Library
Mandarin translation of abstract Medicines that activate cannabinoid CB1 and CB2 receptor
are already in the clinic. These are Cesamet®(nabilone), Marinol®(dronabinol; Δ9 …

Latest advances in cannabinoid receptor agonists

GA Thakur, R Tichkule, S Bajaj… - Expert opinion on …, 2009 - Taylor & Francis
Background: Since the discovery of cannabinoid receptors and their endogenous ligands in
early 1990s, the endocannabinoid system has been shown to play a vital role in several …

Cannabinoid pharmacology: the first 66 years

RG Pertwee - British journal of pharmacology, 2006 - Wiley Online Library
Research into the pharmacology of individual cannabinoids that began in the 1940s, several
decades after the presence of a cannabinoid was first detected in cannabis, is concisely …

The neuropharmacology of cannabinoid receptor ligands in central signaling pathways

TM Brunt, MG Bossong - European Journal of Neuroscience, 2022 - Wiley Online Library
The endocannabinoid system is a complex neuronal system involved in a number of
biological functions, like attention, anxiety, mood, memory, appetite, reward, and immune …

Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures—a short review

I Svíženská, P Dubový, A Šulcová - Pharmacology Biochemistry and …, 2008 - Elsevier
In the last 25 years data has grown exponentially dealing with the discovery of the
endocannabinoid system consisting of specific cannabinoid receptors, their endogenous …

Cannabinoid receptors as therapeutic targets

S Pavlopoulos, GA Thakur, SP Nikas… - Current …, 2006 - ingentaconnect.com
The cannabinoid receptors CB1 and CB2 are family A, G-protein Coupled Receptors that
mediate the effects of cannabinoids, a class of compounds that are so named because the …