A single ip injection of diethylnitrosamine (DEN) or benzo [a] pyrene (BAP) in 1-day-old
female rats produced a high incidence of γ-glutamyltranspeptidase-(GGT)-positive …

A new experimental system was used to examine the stages of chemically induced hepatic
neoplasia in the rat. The treatment protocol involved the ip injection of a single dose of …

An initiation/promotion bioassay for chemical carcinogens and tumor promoters has been
developed in rat liver using presumed preneoplastic lesions, foci of gamma …

Although expression of the enzyme gamma-glutamyl transpeptidase (GGT) is the most
common phenotypic marker of preneoplastic foci in the livers of carcinogen-treated rats, it is …

Basophilic hepatic foci, nodules, and trabecular hepatocellular carcinomas, collectively
referred to as focal hepatic lesions, were induced by single injections of 5.0 micrograms of …

A number of different compounds, including phenobarbital, hypolipidemic drugs such as
clofibrate and nafenopin, the sex steroids progesterone, cyproterone acetate, estradiol and …

Potential synergism between 10 carcinogenic heterocyclic amines [3-amino-l, 4-dimethyl-5
H-pyrido [4, 3-b] indole (Trp-P-1), 3-amino-1-methyl-5 H-pyrido [4, 3-b] indole (Trp-P-2), 2 …

A short-term initiation/promotion bioassay has been developed in rat liver using putative
preneoplastic foci as the endpoint for the detection of chemical carcinogens. The two …

The potential hepatocarcinogenicity of seven pesticides was examined using a rapid
bioassay based on the induction of glutathione S-transferase placental form positive foci in …

The promoting activities of 29 compounds on induction of hyperplastic (neoplastic) liver
nodules (HN) and the dose-dependent effects of tumor promoting agents were compared by …