Both natural products and synthetic organofluorines play important roles in the discovery
and design of pharmaceuticals. The combination of these two classes of molecules has the …

Contributed comment to the special Issue of Medicinal Chemistry Research marking the
retirement of Dr Nicholas Meanwell from Bristol Myers Squibb. The increasing incorporation …

The introduction of fluorine atoms into organic molecules has received considerable
attention as these organofluorines have often found widespread applications in bioorganic …

Nature has hardly evolved a biochemistry of fluorine although there is a low-level
occurrence of fluoroacetate found in selected tropical and subtropical plants. This …

Conspectus The catalytic diversity of living systems offers a broad range of opportunities for
developing new methods to produce small molecule targets such as fuels, materials, and …

In the fields of biologically active materials and functional materials, fluorinated organic
materials are becoming a focus of significant interest. Over the past decade synthetic …

Despite a long and distinguished history focused on the isolation and structural elucidation
of secondary metabolites from all classes of organisms, organic chemists have only securely …

Investigations on diverse aspects of fluoro-organic compounds have rapidly increased
during the past decades. Because natural sources of fluoro-organic compounds are …

Fluorinated compounds are widely used in the fields of molecular imaging, pharmaceuticals,
and materials. Fluorinated natural products in nature are rare, and the introduction of …

Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates
reviews how the use of these techniques on compounds with already known and relevant …