Introduction 3. The cannabinoids: A brief history 3.1. Cannabinoids and the discovery of
cannabinoid receptors 3.2. Endocannabinoids 3.2. 1 Anandamide 3.2. 2 2-arachidonoyl …

Recent studies have demonstrated that the majority of endogenous cannabinoid type 1 (CB
1) receptors do not reach the cell surface but are instead associated with endosomal and …

Cannabinoids are a structurally diverse group of mostly lipophilic molecules that bind to
cannabinoid receptors. In fact, endogenous cannabinoids (endocannabinoids) are a class of …

The effects of the primary psychoactive constituent of marijuana, Δ9-tetrahydrocannabinol,
are mediated by cannabinoid receptors, CB1 and CB2. The CB1 receptors display a unique …

It has long been established that the cannabinoid CB1 receptor transduces signals through
a pertussis toxin-sensitive Gi/Go inhibitory pathway. Although there have been reports that …

The purpose of these studies was to support the hypothesis that an undiscovered
cannabinoid receptor exists in brain.[35S] GTPγS binding was stimulated by anandamide …

Two types of cannabinoid receptor have been discovered so far, CB1 (2.1: CBD: 1: CB1:),
cloned in 1990, and CB2 (2.1: CBD: 2: CB2:), cloned in 1993. Distinction between these …

Since the discovery of an endogenous cannabinoid system, research into the pharmacology
and therapeutic potential of cannabinoids has steadily increased. Two subtypes of G-protein …

The plant Cannabis sativa has been used by humans for thousands of years because of its
psychoactivity. The major psychoactive ingredient of cannabis is δ9–tetrahydrocannabinol …

Two cannabinoid receptors are reviewed with regard to their primary structure, ligand-
binding properties, and signal transduction systems. Both receptors have been cloned; …