Antimicrobial activity of a novel catheter lock solution

CB Shah, MW Mittelman, JW Costerton… - Antimicrobial agents …, 2002 - Am Soc Microbiol
Intravascular catheter-associated bloodstream infections significantly increase rates of
morbidity and hospital costs. Microbial colonization and development of biofilms, which are …

Optimal antimicrobial catheter lock solution, using different combinations of minocycline, EDTA, and 25-percent ethanol, rapidly eradicates organisms embedded in …

I Raad, H Hanna, T Dvorak, G Chaiban… - Antimicrobial agents …, 2007 - Am Soc Microbiol
Antimicrobial lock solutions may be needed to salvage indwelling catheters in patients
requiring continuous intravenous therapy. We determined the activity of minocycline, EDTA …

Activity of novel antibiotic lock solutions in a model against isolates of catheter-related bloodstream infections

PB Bookstaver, JC Williamson… - Annals of …, 2009 - journals.sagepub.com
Background: Catheter-related bloodstream infections (CRBSIs) are a primary concern in
patients with indwelling central venous catheters (CVCs). Instillation of an antibiotic lock …

Tetrasodium EDTA as a novel central venous catheter lock solution against biofilm

SL Percival, P Kite, K Eastwood, R Murga… - Infection Control & …, 2005 - cambridge.org
Background: Central venous catheter (CVC)-related bloodstream infections (BSIs) are
known to increase rates of morbidity and mortality in both inpatients and outpatients …

Elimination of intraluminal colonization by antibiotic lock in silicone vascular catheters

DA Andris, EA Krzywda, CE Edmiston, CJ Krepel… - Nutrition, 1998 - Elsevier
An in vitro model was designed to evaluate the efficacy of instilled antimicrobials to reduce
or eliminate intraluminal microbial colonization. Minimal inhibitory concentration and …

In Vitro Approach for Identification of the Most Effective Agents for Antimicrobial Lock Therapy in the Treatment of Intravascular Catheter-Related Infections Caused by …

S Hogan, M Zapotoczna, NT Stevens… - Antimicrobial Agents …, 2016 - Am Soc Microbiol
Infection of intravascular catheters by Staphylococcus aureus is a significant risk factor
within the health care setting. To treat these infections and attempt salvage of an …

In vitro activity of daptomycin and vancomycin lock solutions on staphylococcal biofilms in a central venous catheter model

KL LaPlante, LA Mermel - Nephrology Dialysis Transplantation, 2007 - academic.oup.com
Background. Catheter lock solutions are used for prevention and management of catheter-
related bloodstream infections. We investigated the activity of daptomycin and vancomycin …

Prophylaxis against dialysis catheter–related bacteremia with a novel antimicrobial lock solution

M Allon - Clinical infectious diseases, 2003 - academic.oup.com
Catheter-related bacteremia, a frequent complication in patients who are undergoing
hemodialysis, may be prevented by eradication of the catheter biofilm. Catheter lock solution …

Microbial inactivation properties of a new antimicrobial/antithrombotic catheter lock solution (citrate/methylene blue/parabens)

J Steczko, SR Ash, DE Nivens, L Brewer… - Nephrology Dialysis …, 2009 - academic.oup.com
Background. Microbial infections are the most serious complications associated with
indwelling central venous catheters. A catheter lock solution that is both antibacterial and …

Randomized controlled trial of taurolidine citrate versus heparin as catheter lock solution in paediatric patients with haematological malignancies

MJ Dümichen, K Seeger, HN Lode, JS Kühl… - Journal of Hospital …, 2012 - Elsevier
BACKGROUND: A catheter lock solution containing 1.35% taurolidine and 4% citrate could
potentially disrupt bacterial surface adherence and consecutive biofilm production due to the …