Divergent adaptive immune responses define two types of long COVID

J Kervevan, I Staropoli, D Slama… - Frontiers in …, 2023 - frontiersin.org
Background The role of adaptive immune responses in long COVID remains poorly
understood, with contrasting hypotheses suggesting either an insufficient antiviral response …

Prolonged T-cell activation and long COVID symptoms independently associate with severe COVID-19 at 3 months

M Santopaolo, M Gregorova, F Hamilton, D Arnold… - Elife, 2023 - elifesciences.org
Abstract Coronavirus disease-19 (COVID-19) causes immune perturbations which may
persist long term, and patients frequently report ongoing symptoms for months after …

Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2

K Yin, MJ Peluso, X Luo, R Thomas, MG Shin… - Nature …, 2024 - nature.com
Long COVID (LC) occurs after at least 10% of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infections, yet its etiology remains poorly understood. We used …

Persistent symptoms after COVID-19 are not associated with differential SARS-CoV-2 antibody or T cell immunity

DM Altmann, CJ Reynolds, G Joy, AD Otter… - Nature …, 2023 - nature.com
Among the unknowns in decoding the pathogenesis of SARS-CoV-2 persistent symptoms in
Long Covid is whether there is a contributory role of abnormal immunity during acute …

[HTML][HTML] Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity

CR Moderbacher, SI Ramirez, JM Dan, A Grifoni… - Cell, 2020 - cell.com
Limited knowledge is available on the relationship between antigen-specific immune
responses and COVID-19 disease severity. We completed a combined examination of all …

Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection

FJ Ryan, CM Hope, MG Masavuli, MA Lynn… - BMC medicine, 2022 - Springer
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly
infectious respiratory virus which is responsible for the coronavirus disease 2019 (COVID …

Remodeling of T cell dynamics during long COVID is dependent on severity of SARS-CoV-2 infection

M Wiech, P Chroscicki, J Swatler, D Stepnik… - Frontiers in …, 2022 - frontiersin.org
Several COVID-19 convalescents suffer from the post-acute COVID-syndrome (PACS)/long
COVID, with symptoms that include fatigue, dyspnea, pulmonary fibrosis, cognitive …

Longitudinal analysis of COVID-19 patients shows age-associated T cell changes independent of ongoing ill-health

L Townsend, AH Dyer, A Naughton, R Kiersey… - Frontiers in …, 2021 - frontiersin.org
Objectives The immunological and inflammatory changes following acute COVID-19 are
hugely variable. Persistent clinical symptoms following resolution of initial infection, termed …

Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals

F Zhang, R Gan, Z Zhen, X Hu, X Li, F Zhou… - Signal transduction and …, 2020 - nature.com
The global Coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has
affected more than eight million people. There is an urgent need to investigate how the …

COVID-19 patients display distinct SARS-CoV-2 specific T-cell responses according to disease severity

M Kroemer, L Spehner, L Vettoretti, A Bouard… - Journal of Infection, 2021 - Elsevier
Adaptive Immune responses generated by SARS-CoV-2 virus in convalescent patients
according to disease severity remain poorly characterized. To this end, we designed a …