Synthesis, molecular docking study of thiazole derivatives and exploring their dual inhibitor potentials against α-amylase and α-glucosidase
Diabetes mellitus is one of the most chronic metabolic diseases. The current study
comprises of evaluation of thiazole as an antidiabetic agent. A library of sixteen derivatives …
comprises of evaluation of thiazole as an antidiabetic agent. A library of sixteen derivatives …
[HTML][HTML] Synthesis, in vitro biological analysis and molecular docking studies of new thiadiazole-based thiourea derivatives as dual inhibitors of a-amylase and a …
Diabetes mellitus is a syndrome that is caused due to the imbalance of insulin production in
the body. In the present study we have synthesized a class of fifteen compounds (1–15) …
the body. In the present study we have synthesized a class of fifteen compounds (1–15) …
New thiazole-based thiazolidinone derivatives: synthesis, in vitro α-amylase, α-glucosidase activities and silico molecular docking study
A series of thiazole-based thiazolidinone derivatives (1-20) have been synthesized and
evaluated against α-glucosidase and α-amylase enzymes. All derivatives showed good α …
evaluated against α-glucosidase and α-amylase enzymes. All derivatives showed good α …
Design, synthesis, in silico testing, and in vitro evaluation of thiazolidinone-based benzothiazole derivatives as inhibitors of α-amylase and α-glucosidase
In this study, a stepwise reaction afforded thiazolidinone-based benzothiazole derivatives 1–
15, and the synthesized derivatives were then screened for biological significance and …
15, and the synthesized derivatives were then screened for biological significance and …
Synthesis of novel benzimidazole-based thiazole derivatives as multipotent inhibitors of α-amylase and α-glucosidase: in vitro evaluation along with molecular …
In this study, hybrid analogs of benzimidazole containing a thiazole moiety (1–17) were
afforded and then tested for their ability to inhibit α-amylase and α-glucosidase when …
afforded and then tested for their ability to inhibit α-amylase and α-glucosidase when …
Synthesis, in vitro α-glucosidase inhibitory activity and molecular docking studies of new thiazole derivatives
Current study based on the synthesis of new thiazole derivatives via “one pot”
multicomponent reaction, evaluation of their in vitro α-glucosidase inhibitory activities, and in …
multicomponent reaction, evaluation of their in vitro α-glucosidase inhibitory activities, and in …
Synthesis, α-amylase inhibitory activity and molecular docking studies of 2, 4-thiazolidinedione derivatives
F Naeem, H Nadeem, A Muhammad… - Open Chemistry …, 2018 - benthamopen.com
Methods: All the synthesized compounds were characterized by elemental analysis, FTIR, 1
HNMR, and 13 CNMR and further screened for their α-amylase inhibitory potential. Results …
HNMR, and 13 CNMR and further screened for their α-amylase inhibitory potential. Results …
[HTML][HTML] New quinoline-based triazole hybrid analogs as effective inhibitors of α-amylase and α-glucosidase: Preparation, in vitro evaluation, and molecular docking …
The 7-quinolinyl bearing triazole analogues were synthesized (1-19) and according to
literature known protocol were screened in vitro for their α-amylase and α-glucosidase …
literature known protocol were screened in vitro for their α-amylase and α-glucosidase …
Syntheses, in vitro α-amylase and α-glucosidase dual inhibitory activities of 4-amino-1, 2, 4-triazole derivatives their molecular docking and kinetic studies
Abstract Thirty-three 4-amino-1, 2, 4-triazole derivatives 1–33 were synthesized by reacting
4-amino-1, 2, 4-triazole with a variety of benzaldehydes. The synthetic molecules were …
4-amino-1, 2, 4-triazole with a variety of benzaldehydes. The synthetic molecules were …
Synthesis, in vitro α-glucosidase and α-amylase activities and molecular docking study of oxadiazole-sulphonamide hybrid analogues
Acarbose and voglibose are two different α-glucosidase and α-amylase inhibitors that are
used to manage diabetes mellitus. Sadly, these renowned and therapeutically effective …
used to manage diabetes mellitus. Sadly, these renowned and therapeutically effective …