Our objective was to investigate the expression of different cytochromes P450 3A (CYP3A4,
CYP3A5, and CYP3A7) and P‐glycoprotein (ABCB1) genes along the human large intestine …

Objectives Our objectives were to determine the content of cytochrome P450 (CYP) 3A4,
CYP3A5, and P‐glycoprotein and to measure CYP3A4‐dependent catalytic activity in paired …

Human small intestine epithelial cells (enterocytes) provide the first site for cytochrome P-
450 (CYP)-catalyzed metabolism of orally ingested xenobiotics. The CYP composition of …

SUMMARY 1 CYP3A isoforms metabolise a diverse array of clinically important drugs and P‐
glycoprotein (P‐gp), a transmembrane efflux pump, can extrude a wide variety of drugs from …

Background The small intestine is receiving increased attention for its importance in drug
metabolism. However, knowledge of the intervariability and regulation of the enzymes …

Abstract Background Cytochrome P450 (CYP) enzymes in epithelial cells lining the
alimentary tract play an important role in both the elimination and activation of (pro-) …

Background Despite the fact that the alimentary tract is part of the body's first line of defense
against orally ingested xenobiotica, little is known about the distribution and expression of …

Aims To characterize mRNA expression levels (17 cytochromes P450) and activity (9
isoforms) of major cytochromes P450 expressed throughout the human small intestine …

Intestinal cytochrome P450 (P450) proteins play an important role in the biotransformation of
drugs and may significantly limit their oral absorption and bioavailability. Therefore, we have …

The level of expression of genes encoding for nine major xenobiotic metabolising
Cytochrome P450s (CYPs) and the P-glycoprotein (Pgp) was determined in three different …