As there is effective intervention for delaying or preventing metabolic diseases, which are
often present for years before becoming clinically apparent, novel biomarkers that would …

OBJECTIVE To conduct a systematic review of cross-sectional and prospective human
studies evaluating metabolite markers identified using high-throughput metabolomics …

Conclusion Amino acid profiling of biological samples could be used to generate indices
that could be used for clinical diagnosis and is a useful tool for understanding metabolic …

Dysregulation of insulin action is most often considered in the context of impaired glucose
homeostasis, with the defining feature of diabetes mellitus being elevated blood glucose …

Objectives The objective of the study is to evaluate whether plasma amino acid (AA)
differences are related with obesity or diabetes. Design and methods In 126 diabetes and …

Background A strong association of obesity and insulin resistance with increased circulating
levels of branched-chain and aromatic amino acids and decreased glycine levels has been …

Aims Prior studies have reported that elevated concentrations of several plasma amino
acids (AA), particularly branched chain (BCAA) and aromatic AA predict the onset of type 2 …

The perturbation in plasma free amino acid metabolome has been observed previously in
diabetes mellitus, and is associated with insulin resistance as well as the onset of …

INTRODUCTION: Amino acids are important modulators of glucose metabolism, insulin
secretion and insulin sensitivity. However, little is known about the changes in amino acid …

Objective Elevated circulating levels of branched chain and aromatic amino acids
(BCAA/AAAs) are associated with insulin resistance and incident type 2 diabetes (T2D) …