A subgroup of obese individuals, referred to as metabolically healthy obese (MHO), have
preserved insulin sensitivity and a normal lipid profile despite being obese. The molecular …

Altered plasma levels of branched-chain amino acids (BCAAs) and aromatic amino acids
(AAAs) may predict the development of insulin resistance and other type 2 diabetes mellitus …

Peripheral resistance to insulin action is the major mechanism causing the metabolic
syndrome and eventually type 2 diabetes mellitus. The metabolic derangement associated …

The quantitation of free amino acids from physiologic samples is essential for diagnosing
and monitoring patients with inherited metabolic disorders. Current methods are hindered by …

Aims/hypotheses We aimed to quantify the association of individual circulating amino acids
with macrovascular disease, microvascular disease and all-cause mortality in individuals …

Background Epidemiological studies have shown that increased circulating branched-chain
amino acids (BCAAs) are associated with insulin resistance and type 2 diabetes (T2D). This …

Background Women with a history of gestational diabetes mellitus (GDM) have a 7-fold
higher risk of developing type 2 diabetes (T2D) during midlife and an elevated risk of …

OBJECTIVE To determine whether circulating metabolic intermediates are related to insulin
resistance and β-cell dysfunction in individuals at risk for type 2 diabetes. RESEARCH …

Quantifying amino acids in biological matrices is typically performed using liquid
chromatography (LC) coupled with fluorescent detection (FLD), requiring both derivatization …

Context: Metabolomic profiling of amino acids and acylcarnitines has revealed consistent
patterns associated with metabolic disease. Objective: This study used metabolomic …