This review summarizes recent findings on peripheral mechanisms underlying the
generation and inhibition of pain. The focus is on events occurring in peripheral injured …

Inhibitory synaptic transmission in the dorsal horn (DH) of the spinal cord plays an important
role in the modulation of nociceptive messages because pharmacological blockade of …

Chronic pain, whether the result of nerve trauma or persistent inflammation, is a debilitating
condition that exerts a high social cost in terms of productivity, economic impact and quality …

Over the last twenty years of research on cellular mechanisms of pain hypersensitivity, long‐
term potentiation (LTP) of synaptic transmission in the spinal cord dorsal horn (DH) has …

Activation of glial cells and neuro–glial interactions are emerging as key mechanisms
underlying chronic pain. Accumulating evidence has implicated 3 types of glial cells in the …

Objectives: This review discusses plasticity of excitatory synaptic transmission in the spinal
dorsal horn and the role of this plasticity in contributing to the pathogenesis of pain …

The use of genetically-engineered mice has identified α2-and α3-subunit containing GABA
A receptors as principal contributors to the spinal disinhibition that occurs after inflammation …

Admiral Lord Nelson lost his right arm in a sea battle some years before his successful
encounter with the forces of Napoleon at the Battle of Trafalgar (1805). Like virtually all …

The prevalence and severity of many chronic pain syndromes differ across sex, and recent
studies have identified differences in immune signalling within spinal nociceptive circuits as …