After spinal cord injury (SCI), between 10% and 20% of the patients may develop central
neuropathic pain. This type of chronic pain usually is a very bothersome sequel and …

Nociceptive pain alerts the body to potential or actual tissue damage. By contrast,
neuropathic pain, which results from injury or damage to the nervous system, persists long …

Considerable functional and structural alterations, or plasticity, in the central nervous system
(CNS) are accompanied by numerous chronic pain syndromes. Sensitization of the …

Neuropathic pain is a disease of global burden. Its symptoms include spontaneous and
stimulus-evoked painful sensations. Several maladaptive mechanisms underlying these …

Therapeutic management of chronic pain has not been widely successful owing to a lack of
understanding of factors that initiate and maintain the chronic pain condition. Efforts to …

Glial cells play an essential role in maintaining the proper functioning of the nervous system.
They are more abundant than neurons in most neural tissues and provide metabolic and …

Pain hypersensitivity that develops after tissue or nerve injury is dependent both on
peripheral processes in the affected tissue and on enhanced neuronal responses in the …

Neuropathic pain is a debilitating condition resulting from damage to the nervous system.
Imbalance of spinal excitation and inhibition has been proposed to contribute to neuropathic …

Neuropathic pain refers to a specific pain syndrome characterized by pain and sensory
abnormalities in body parts that have lost their normal peripheral innervation or sensory …

Neuropathic pain syndromes—pain after a lesion or disease of the peripheral or central
nervous system—are clinically characterized by spontaneous and evoked types of pain …