[HTML][HTML] Engineered tumor-targeted T cells mediate enhanced anti-tumor efficacy both directly and through activation of the endogenous immune system
MP Avanzi, O Yeku, X Li, DP Wijewarnasuriya… - Cell reports, 2018 - cell.com
Chimeric antigen receptor (CAR) T cell therapy has proven clinically beneficial against B cell
acute lymphoblastic leukemia and non-Hodgkin's lymphoma. However, suboptimal clinical …
acute lymphoblastic leukemia and non-Hodgkin's lymphoma. However, suboptimal clinical …
T cells derived from human melanoma draining lymph nodes mediate melanoma-specific antitumor responses in vitro and in vivo in human melanoma xenograft …
M Zhang, H Graor, A Visioni, M Strohl… - Journal of …, 2015 - journals.lww.com
It has been established in murine models that lymph nodes draining a progressively growing
tumor contain antigen-specific T cells capable of mediating protective immune responses …
tumor contain antigen-specific T cells capable of mediating protective immune responses …
An expanded peripheral T cell population to a cytotoxic T lymphocyte (CTL)-defined, melanocyte-specific antigen in metastatic melanoma patients impacts on …
A Anichini, A Molla, R Mortarini, G Tragni… - The Journal of …, 1999 - rupress.org
It is not known if immune response to T cell–defined human histocompatibility leukocyte
antigen (HLA) class I–restricted melanoma antigens leads to an expanded peripheral pool …
antigen (HLA) class I–restricted melanoma antigens leads to an expanded peripheral pool …
A simplified method for the clinical-scale generation of central memory-like CD8+ T cells after transduction with lentiviral vectors encoding antitumor antigen T-cell …
S Yang, ME Dudley, SA Rosenberg… - Journal of …, 2010 - journals.lww.com
Adoptive transfer of antigen-specific CD8+ T cells can effectively treat patients with
metastatic melanoma. Recent efforts have emphasized the in vitro generation of antitumor T …
metastatic melanoma. Recent efforts have emphasized the in vitro generation of antitumor T …
[HTML][HTML] Synergy of brief activation of CD8 T-cells in the presence of IL-12 and adoptive transfer into lymphopenic hosts promotes tumor clearance and anti-tumor …
CM Díaz-Montero, O Naga, AAA Zidan… - American journal of …, 2011 - ncbi.nlm.nih.gov
Adoptive T-cell therapy holds great promise for the treatment of metastatic melanoma.
However, prohibitive costs associated with current technology required for culture and …
However, prohibitive costs associated with current technology required for culture and …
[HTML][HTML] Neoantigen-reactive CD8+ T cells affect clinical outcome of adoptive cell therapy with tumor-infiltrating lymphocytes in melanoma
NP Kristensen, C Heeke… - The Journal of …, 2022 - Am Soc Clin Investig
BACKGROUND. Neoantigen-driven recognition and T cell–mediated killing contribute to
tumor clearance following adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes …
tumor clearance following adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes …
Human autologous tumor-specific T cells in malignant melanoma
CD Platsoucas - Cancer and Metastasis Reviews, 1991 - Springer
T cell lines and clones with autologous tumor-specific activity have been developed in
malignant melanoma by stimulating peripheral blood lymphocytes (PBL), lymph node …
malignant melanoma by stimulating peripheral blood lymphocytes (PBL), lymph node …
Molecular Mechanism of MART-1+/A*0201+ Human Melanoma Resistance to Specific CTL-Killing Despite Functional Tumor–CTL Interaction
AR Jazirehi, S Baritaki, RC Koya, B Bonavida… - Cancer research, 2011 - AACR
Durable responses in metastatic melanoma patients remain generally difficult to achieve.
Adoptive cell therapy (ACT) with ex vivo engineered lymphocytes expressing high affinity T …
Adoptive cell therapy (ACT) with ex vivo engineered lymphocytes expressing high affinity T …
Simultaneous coexpression of memory-related and effector-related genes by individual human CD8 T cells depends on antigen specificity and differentiation
B Gupta, EM Iancu, PO Gannon… - Journal of …, 2012 - journals.lww.com
Phenotypic and functional cell properties are usually analyzed at the level of defined cell
populations but not single cells. Yet, large differences between individual cells may have …
populations but not single cells. Yet, large differences between individual cells may have …
Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen
Gene therapy of human cancer using genetically engineered lymphocytes is dependent on
the identification of highly reactive T-cell receptors (TCRs) with antitumor activity. We …
the identification of highly reactive T-cell receptors (TCRs) with antitumor activity. We …