HIV‐1 Nef: taking control of protein trafficking
EA Pereira, LLP daSilva - Traffic, 2016 - Wiley Online Library
The Nef protein of the human immunodeficiency virus is a crucial determinant of viral
pathogenesis and disease progression. Nef is abundantly expressed early in infection and …
pathogenesis and disease progression. Nef is abundantly expressed early in infection and …
How HIV Nef proteins hijack membrane traffic to promote infection
The accessory protein Nef of human immunodeficiency virus (HIV) is a primary determinant
of viral pathogenesis. Nef is abundantly expressed during infection and reroutes a variety of …
of viral pathogenesis. Nef is abundantly expressed during infection and reroutes a variety of …
Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways
JF Roeth, KL Collins - Microbiology and molecular biology reviews, 2006 - Am Soc Microbiol
The Nef protein of primate lentiviruses is a unique protein that has evolved in several ways
to manipulate the biology of an infected cell to support viral replication, immune evasion …
to manipulate the biology of an infected cell to support viral replication, immune evasion …
Implications of Nef: host cell interactions in viral persistence and progression to AIDS
NJ Arhel, F Kirchhoff - HIV Interactions with Host Cell Proteins, 2009 - Springer
Abstract The HIV and SIV Nef accessory proteins are potent enhancers of viral persistence
and accelerate progression to AIDS in HIV-1-infected patients and non-human primate …
and accelerate progression to AIDS in HIV-1-infected patients and non-human primate …
Human immunodeficiency virus type 1 Nef functions at the level of virus entry by enhancing cytoplasmic delivery of virions
E Schaeffer, R Geleziunas, WC Greene - Journal of virology, 2001 - Am Soc Microbiol
The Nef protein of the type 1 human immunodeficiency virus (HIV-1) plays a key although
poorly understood role in accelerating the progression of clinical disease in vivo. Nef exerts …
poorly understood role in accelerating the progression of clinical disease in vivo. Nef exerts …
HIV immune evasion: disruption of antigen presentation by the HIV Nef protein
ER Wonderlich, JA Leonard, KL Collins - Advances in virus research, 2011 - Elsevier
Abstract The Human Immunodeficiency Virus (HIV) Nef protein is necessary for high viral
loads and for timely progression to AIDS. Nef plays a number of roles, but its effect on …
loads and for timely progression to AIDS. Nef plays a number of roles, but its effect on …
[HTML][HTML] Structure–function relationships in HIV‐1 Nef
M Geyer, OT Fackler, BM Peterlin - EMBO reports, 2001 - embopress.org
The accessory Nef protein of HIV and SIV is essential for viral pathogenesis, yet it is
perplexing in its multitude of molecular functions. In this review we analyse the structure …
perplexing in its multitude of molecular functions. In this review we analyse the structure …
HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elements
JA Leonard, T Filzen, CC Carter, M Schaefer… - Journal of …, 2011 - Am Soc Microbiol
The Nef protein is an important HIV virulence factor that promotes the degradation of host
proteins to augment virus production and facilitate immune evasion. The best-characterized …
proteins to augment virus production and facilitate immune evasion. The best-characterized …
HIV-1 Nef: a multifaceted modulator of T cell receptor signaling
L Abraham, OT Fackler - Cell communication and signaling, 2012 - Springer
Nef, an accessory protein of the Human Immunodeficiency Virus type 1 (HIV-1), is
dispensable for viral replication in cell culture, but promotes virus replication and …
dispensable for viral replication in cell culture, but promotes virus replication and …
The Nef-infectivity enigma: mechanisms of enhanced lentiviral infection
J Vermeire, G Vanbillemont, W Witkowski… - Current HIV …, 2011 - ingentaconnect.com
The Nef protein is an essential factor for lentiviral pathogenesis in humans and other
simians. Despite a multitude of functions attributed to this protein, the exact role of Nef in …
simians. Despite a multitude of functions attributed to this protein, the exact role of Nef in …